|
|
| Line 7: |
Line 7: |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=294d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=294d OCA], [https://pdbe.org/294d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=294d RCSB], [https://www.ebi.ac.uk/pdbsum/294d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=294d ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=294d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=294d OCA], [https://pdbe.org/294d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=294d RCSB], [https://www.ebi.ac.uk/pdbsum/294d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=294d ProSAT]</span></td></tr> |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
| |
| == Publication Abstract from PubMed ==
| |
| The cytosine-rich strand of the Tetrahymena telomere consists of multiple repeats of sequence d(AACCCC). We have solved the crystal structure of the crystalline repeat sequence at 2.5 A resolution. The adenines form two different and previously unknown clusters (A clusters) in orthogonal directions with their counterparts from other strands, each containing a total of eight adenines. The clusters appear to be stable aggregates held together by base stacking and three different base-pairing modes. Two different types of cytosine tetraplexes are found in the crystal. Each four-stranded complex is composed of two intercalated parallel-stranded duplexes pointing in opposite directions, with hemiprotonated cytosine-cytosine (C.C+) base pairs. The outermost C.C+base pairs are from the 5'-end of each strand in one cytosine tetraplex and from the 3'-end of each strand in the other. The A clusters and the cytosine tetraplexes form two alternating stacking patterns, creating continuous base stacking in two perpendicular directions along the x - and z -axes. The adenine clusters could be organizational motifs for macromolecular RNA.
| |
|
| |
| Intercalated cytosine motif and novel adenine clusters in the crystal structure of the Tetrahymena telomere.,Cai L, Chen L, Raghavan S, Ratliff R, Moyzis R, Rich A Nucleic Acids Res. 1998 Oct 15;26(20):4696-705. PMID:9753739<ref>PMID:9753739</ref>
| |
|
| |
| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| |
| </div>
| |
| <div class="pdbe-citations 294d" style="background-color:#fffaf0;"></div>
| |
| == References ==
| |
| <references/>
| |
| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
