2cro: Difference between revisions

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<StructureSection load='2cro' size='340' side='right'caption='[[2cro]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='2cro' size='340' side='right'caption='[[2cro]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2cro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bp434 Bp434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CRO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2cro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phage_434 Phage 434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CRO FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cro OCA], [https://pdbe.org/2cro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cro RCSB], [https://www.ebi.ac.uk/pdbsum/2cro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cro ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cro OCA], [https://pdbe.org/2cro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cro RCSB], [https://www.ebi.ac.uk/pdbsum/2cro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cro ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RCRO_BP434 RCRO_BP434]] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.  
[https://www.uniprot.org/uniprot/RCRO_BP434 RCRO_BP434] Cro represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operators regions normally used by the repressor protein for lysogenic maintenance.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cro ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cro ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of phage 434 Cro protein has been determined and refined against 2.35 A data to an R-factor of 19.5%. The protein comprises five alpha-helices and shows the helix-turn-helix motif found in other repressor proteins.
Structure of phage 434 Cro protein at 2.35 A resolution.,Mondragon A, Wolberger C, Harrison SC J Mol Biol. 1989 Jan 5;205(1):179-88. PMID:2647998<ref>PMID:2647998</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2cro" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bp434]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Harrison, S C]]
[[Category: Phage 434]]
[[Category: Mondragon, A]]
[[Category: Harrison SC]]
[[Category: Wolberger, C]]
[[Category: Mondragon A]]
[[Category: Gene regulating protein]]
[[Category: Wolberger C]]
Retrieved from "https://proteopedia.org/2cro"