2fg5: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2fg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FG5 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2FG5 FirstGlance].

<table><tr><td colspan='2'>[[2fg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FG5 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2FG5 FirstGlance].

</td></tr><tr id='~~ligand~~'><td class="sblockLbl">[[~~Ligand~~|~~Ligands~~:]]</td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID~~-~~GUANYLATE+ESTER'>GNP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801Å</td></tr>

<tr id='~~gene~~'><td class="sblockLbl">[[~~Gene~~|~~Gene~~:]]</td><td class="sblockDat">~~RAB31, RAB22B ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=2fg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fg5 OCA], [https://pdbe.org/2fg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fg5 RCSB], [https://www.ebi.ac.uk/pdbsum/2fg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fg5 ProSAT]</td></tr>

</table>

== Function ==

[[https://www.uniprot.org/uniprot/RAB31_HUMAN RAB31_HUMAN]] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:17678623</ref> <ref>PMID:17189207</ref> <ref>PMID:19725050</ref> <ref>PMID:21586568</ref> <ref>PMID:21255211</ref>

[https://www.uniprot.org/uniprot/RAB31_HUMAN RAB31_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:17678623</ref> <ref>PMID:17189207</ref> <ref>PMID:19725050</ref> <ref>PMID:21586568</ref> <ref>PMID:21255211</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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__TOC__

</StructureSection>

[[Category: ~~Human~~]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith, C]]

[[Category: Arrowsmith C]]

[[Category: Bochkarev, A]]

[[Category: Bochkarev A]]

[[Category: Edwards, A]]

[[Category: Edwards A]]

[[Category: Ismail, S]]

[[Category: Ismail S]]

[[Category: Park, H]]

[[Category: Park H]]

~~[[Category: Structural genomic~~]]

[[Category: Sundstrom M]]

[[Category: Sundstrom, M]]

[[Category: Tempel W]]

[[Category: Tempel, W]]

[[Category: Wang J]]

[[Category: Wang, J]]

[[Category: Weigelt J]]

[[Category: Weigelt, J]]

~~[[Category: G-protein]]~~

~~[[Category: Gtp analogue]]~~

~~[[Category: Rab]]~~

~~[[Category: Sgc]]~~

~~[[Category: Signaling protein~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='2fg5' size='340' side='right'caption='[[2fg5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2fg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FG5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2fg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FG5 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAB31, RAB22B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fg5 OCA], [https://pdbe.org/2fg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fg5 RCSB], [https://www.ebi.ac.uk/pdbsum/2fg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fg5 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/RAB31_HUMAN RAB31_HUMAN]] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:17678623</ref> <ref>PMID:17189207</ref> <ref>PMID:19725050</ref> <ref>PMID:21586568</ref> <ref>PMID:21255211</ref>
+[https://www.uniprot.org/uniprot/RAB31_HUMAN RAB31_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:17678623</ref> <ref>PMID:17189207</ref> <ref>PMID:19725050</ref> <ref>PMID:21586568</ref> <ref>PMID:21255211</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 27: / Line 27: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Arrowsmith, C]]
+[[Category: Arrowsmith C]]
-[[Category: Bochkarev, A]]
+[[Category: Bochkarev A]]
-[[Category: Edwards, A]]
+[[Category: Edwards A]]
-[[Category: Ismail, S]]
+[[Category: Ismail S]]
-[[Category: Park, H]]
+[[Category: Park H]]
-[[Category: Structural genomic]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M]]
+[[Category: Tempel W]]
-[[Category: Tempel, W]]
+[[Category: Wang J]]
-[[Category: Wang, J]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J]]
-[[Category: G-protein]]
-[[Category: Gtp analogue]]
-[[Category: Rab]]
-[[Category: Sgc]]
-[[Category: Signaling protein]]