8ceg: Difference between revisions
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==BAR domain protein FAM92A1 essential for mitochondrial membrane remodeling== | |||
<StructureSection load='8ceg' size='340' side='right'caption='[[8ceg]], [[Resolution|resolution]] 2.03Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8ceg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CEG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ceg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ceg OCA], [https://pdbe.org/8ceg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ceg RCSB], [https://www.ebi.ac.uk/pdbsum/8ceg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ceg ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Fudo | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/CBAR1_HUMAN CBAR1_HUMAN] Postaxial polydactyly type A. The disease may be caused by variants affecting the gene represented in this entry. | ||
[[Category: Yan | == Function == | ||
[https://www.uniprot.org/uniprot/CBAR1_HUMAN CBAR1_HUMAN] Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis (PubMed:27528616, PubMed:30395363). In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616, PubMed:30395363). Plays an important role in the mitochondrial function and is essential for maintaining mitochondrial morphology and inner membrane ultrastructure (PubMed:30404948). In vitro, can generate membrane curvature through preferential interaction with negatively charged phospholipids such as phosphatidylinositol 4,5-bisphosphate and cardiolipin and hence orchestrate cristae shape (PubMed:30404948).[UniProtKB:Q8BP22]<ref>PMID:27528616</ref> <ref>PMID:30395363</ref> <ref>PMID:30404948</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Fudo S]] | |||
[[Category: Kajander T]] | |||
[[Category: Yan Z]] | |||
[[Category: Zhao H]] | |||
Revision as of 08:52, 21 February 2024
BAR domain protein FAM92A1 essential for mitochondrial membrane remodeling
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