8rij: Difference between revisions

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'''Unreleased structure'''


The entry 8rij is ON HOLD  until Paper Publication
==Discovery of the first orally bioavailable ADAMTS7 inhibitor BAY-9835==
 
<StructureSection load='8rij' size='340' side='right'caption='[[8rij]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8rij]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RIJ FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1H07:~{N}-[[(4~{R})-4-cyclopropyl-2,5-bis(oxidanylidene)imidazolidin-4-yl]methyl]-2-(3-fluorophenyl)-1,2,3-triazole-4-carboxamide'>A1H07</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rij OCA], [https://pdbe.org/8rij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rij RCSB], [https://www.ebi.ac.uk/pdbsum/8rij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rij ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Beyer K]]
[[Category: Broehl A]]
[[Category: Cancho-Grande Y]]
[[Category: Elowe N]]
[[Category: Henninger K]]
[[Category: Johannes S]]
[[Category: Jungmann N]]
[[Category: Krainz T]]
[[Category: Lindner N]]
[[Category: Maassen S]]
[[Category: MacDonald B]]
[[Category: Meibom D]]
[[Category: Menshykau D]]
[[Category: Mittendorf J]]
[[Category: Sanchez G]]
[[Category: Schafer M]]
[[Category: Stefan E]]
[[Category: Torge A]]
[[Category: Wasnaire P]]
[[Category: Xing Y]]
[[Category: Zubov D]]
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