3c5h: Difference between revisions

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<StructureSection load='3c5h' size='340' side='right'caption='[[3c5h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3c5h' size='340' side='right'caption='[[3c5h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3c5h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5H FirstGlance]. <br>
<table><tr><td colspan='2'>[[3c5h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRLF1, GRF1, KIAA1722 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5h OCA], [https://pdbe.org/3c5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5h RCSB], [https://www.ebi.ac.uk/pdbsum/3c5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5h OCA], [https://pdbe.org/3c5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5h RCSB], [https://www.ebi.ac.uk/pdbsum/3c5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RHG35_HUMAN RHG35_HUMAN]] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.<ref>PMID:1894621</ref>
[https://www.uniprot.org/uniprot/RHG35_HUMAN RHG35_HUMAN] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.<ref>PMID:1894621</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A]]
[[Category: Bochkarev A]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: MacKenzie, F]]
[[Category: MacKenzie F]]
[[Category: Park, H]]
[[Category: Park H]]
[[Category: Structural genomic]]
[[Category: Shen L]]
[[Category: Shen, L]]
[[Category: Tempel W]]
[[Category: Tempel, W]]
[[Category: Tong Y]]
[[Category: Tong, Y]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Alternative splicing]]
[[Category: Anti-oncogene]]
[[Category: Cell cycle]]
[[Category: Cytoplasm]]
[[Category: Dna-binding]]
[[Category: Glucorticoid receptor]]
[[Category: Gtpase]]
[[Category: Gtpase activation]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Ra]]
[[Category: Repressor]]
[[Category: Sgc]]
[[Category: Signaling protein]]
[[Category: Transcription]]
[[Category: Transcription regulation]]

Latest revision as of 09:33, 21 February 2024

Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP)

3c5h, resolution 1.80Å

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