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<StructureSection load='3dad' size='340' side='right'caption='[[3dad]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3dad' size='340' side='right'caption='[[3dad]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3dad]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAD FirstGlance]. <br>
<table><tr><td colspan='2'>[[3dad]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DAD FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FHOD1, FHOS, FHOS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dad OCA], [https://pdbe.org/3dad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dad RCSB], [https://www.ebi.ac.uk/pdbsum/3dad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dad ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dad OCA], [https://pdbe.org/3dad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dad RCSB], [https://www.ebi.ac.uk/pdbsum/3dad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dad ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FHOD1_HUMAN FHOD1_HUMAN]] Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.<ref>PMID:14576350</ref> <ref>PMID:15878344</ref> <ref>PMID:18694941</ref>
[https://www.uniprot.org/uniprot/FHOD1_HUMAN FHOD1_HUMAN] Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.<ref>PMID:14576350</ref> <ref>PMID:15878344</ref> <ref>PMID:18694941</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dad ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dad ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Formins induce the nucleation and polymerization of unbranched actin filaments. They share three homology domains required for profilin binding, actin polymerization, and regulation. Diaphanous-related formins (DRFs) are activated by GTPases of the Rho/Rac family, whose interaction with the N-terminal formin domain is thought to displace a C-terminal Diaphanous-autoregulatory domain (DAD). We have determined the structure of the N-terminal domains of FHOD1 consisting of a GTPase-binding domain (GBD) and the DAD-recognition domain FH3. In contrast to the formin mDia1, the FHOD1-GBD reveals a ubiquitin superfold as found similarly in c-Raf1 or PI3 kinase. This GBD is recruited by Rac and Ras GTPases in cells and plays an essential role for FHOD1-mediated actin remodeling. The FHOD1-FH3 domain is composed of five armadillo repeats, similarly to other formins. Mutation of one residue in the predicted DAD-interaction surface efficiently activates FHOD1 in cells. These results demonstrate that DRFs have evolved different molecular solutions to govern their autoregulation and GTPase specificity.
The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation.,Schulte A, Stolp B, Schonichen A, Pylypenko O, Rak A, Fackler OT, Geyer M Structure. 2008 Sep 10;16(9):1313-23. PMID:18786395<ref>PMID:18786395</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3dad" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fackler, O T]]
[[Category: Fackler OT]]
[[Category: Geyer, M]]
[[Category: Geyer M]]
[[Category: Pylypenko, O]]
[[Category: Pylypenko O]]
[[Category: Rak, A]]
[[Category: Rak A]]
[[Category: Schonichen, A]]
[[Category: Schonichen A]]
[[Category: Schulte, A]]
[[Category: Schulte A]]
[[Category: Stolp, B]]
[[Category: Stolp B]]
[[Category: Actin-binding]]
[[Category: Armadillo repeat]]
[[Category: Coiled coil]]
[[Category: Cytoplasm]]
[[Category: Cytoskeleton]]
[[Category: Fhod1]]
[[Category: Formin]]
[[Category: Gtpase-binding domain]]
[[Category: Phosphoprotein]]
[[Category: Signaling protein]]
[[Category: Ubiquitin-superfold]]
Retrieved from "https://proteopedia.org/3dad"