3gm7: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3gm7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GM7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3gm7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GM7 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zev|1zev]], [[3glp|3glp]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gm7 OCA], [https://pdbe.org/3gm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gm7 RCSB], [https://www.ebi.ac.uk/pdbsum/3gm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gm7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gm7 OCA], [https://pdbe.org/3gm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gm7 RCSB], [https://www.ebi.ac.uk/pdbsum/3gm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gm7 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Myotonic dystrophy (DM) type 1 is associated with an expansion of (&gt;50) CTG repeats within the 3' untranslated region (UTR) of the dystrophin myotonin protein kinase gene (dmpk). In the corresponding mRNA transcript, the CUG repeats form an extended stem-loop structure. The double-stranded RNA of the stem sequesters RNA binding proteins away from their normal cellular targets resulting in aberrant transcription, alternative splicing patterns, or both, thereby leading to DM. To better understand the structural basis of DM type 1, we determined to 1.58-A resolution the x-ray crystal structure of an 18-bp RNA containing six CUG repeats. The CUG repeats form antiparallel double-stranded helices that stack end-on-end in the crystal to form infinite, pseudocontinuous helices similar to the long CUG stem loops formed by the expanded CUG repeats in DM type 1. The CUG helix is very similar in structure to A-form RNA with the exception of the unique U-U mismatches. This structure provides a high-resolution view of a toxic, trinucleotide repeat RNA.
The structural basis of myotonic dystrophy from the crystal structure of CUG repeats.,Mooers BH, Logue JS, Berglund JA Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16626-31. Epub 2005 Nov 3. PMID:16269545<ref>PMID:16269545</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3gm7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kierzek, R]]
[[Category: Kierzek R]]
[[Category: Kiliszek, A]]
[[Category: Kiliszek A]]
[[Category: Krzyzosiak, W J]]
[[Category: Krzyzosiak WJ]]
[[Category: Rypniewski, W]]
[[Category: Rypniewski W]]
[[Category: Cug repeat]]
[[Category: Myotonic dystrophy]]
[[Category: Rna]]
[[Category: Stretched u-u wobble]]

Latest revision as of 09:55, 21 February 2024

1.58 A resolution X-ray structure of (CUG)6

3gm7, resolution 1.58Å

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