3hx4: Difference between revisions

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<StructureSection load='3hx4' size='340' side='right'caption='[[3hx4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3hx4' size='340' side='right'caption='[[3hx4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3hx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HX4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3hx4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HX4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TGME49_101440, CDPK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx4 OCA], [https://pdbe.org/3hx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hx4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hx4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hx4 OCA], [https://pdbe.org/3hx4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hx4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hx4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hx4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9BJF5_TOXGO Q9BJF5_TOXGO]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hx4 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hx4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Calcium-dependent protein kinases (CDPKs) have pivotal roles in the calcium-signaling pathway in plants, ciliates and apicomplexan parasites and comprise a calmodulin-dependent kinase (CaMK)-like kinase domain regulated by a calcium-binding domain in the C terminus. To understand this intramolecular mechanism of activation, we solved the structures of the autoinhibited (apo) and activated (calcium-bound) conformations of CDPKs from the apicomplexan parasites Toxoplasma gondii and Cryptosporidium parvum. In the apo form, the C-terminal CDPK activation domain (CAD) resembles a calmodulin protein with an unexpected long helix in the N terminus that inhibits the kinase domain in the same manner as CaMKII. Calcium binding triggers the reorganization of the CAD into a highly intricate fold, leading to its relocation around the base of the kinase domain to a site remote from the substrate binding site. This large conformational change constitutes a distinct mechanism in calcium signal-transduction pathways.
Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.,Wernimont AK, Artz JD, Finerty P Jr, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R Nat Struct Mol Biol. 2010 May;17(5):596-601. Epub 2010 May 2. PMID:20436473<ref>PMID:20436473</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3hx4" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Calcium-dependent protein kinase|Calcium-dependent protein kinase]]
*[[Calcium-dependent protein kinase|Calcium-dependent protein kinase]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Toxgo]]
[[Category: Toxoplasma gondii]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Artz, J D]]
[[Category: Artz JD]]
[[Category: Bochkarev, A]]
[[Category: Bochkarev A]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Finnerty, P]]
[[Category: Finnerty P]]
[[Category: Hassani, A A]]
[[Category: Hassani AA]]
[[Category: He, H]]
[[Category: He H]]
[[Category: Hui, R]]
[[Category: Hui R]]
[[Category: Lin, Y H]]
[[Category: Lin YH]]
[[Category: Lourido, S]]
[[Category: Lourido S]]
[[Category: MacKenzie, F]]
[[Category: MacKenzie F]]
[[Category: Structural genomic]]
[[Category: Sibley DL]]
[[Category: Sibley, D L]]
[[Category: Sinestera G]]
[[Category: Sinestera, G]]
[[Category: Vedadi M]]
[[Category: Vedadi, M]]
[[Category: Wasney G]]
[[Category: Wasney, G]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Wernimont AK]]
[[Category: Wernimont, A K]]
[[Category: Xiao T]]
[[Category: Xiao, T]]
[[Category: Atp-binding]]
[[Category: Cdpk]]
[[Category: Kinase]]
[[Category: Nucleotide-binding]]
[[Category: Protist]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Sgc]]
[[Category: Toxoplasma]]
[[Category: Transferase]]
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