3iby: Difference between revisions

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<StructureSection load='3iby' size='340' side='right'caption='[[3iby]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3iby' size='340' side='right'caption='[[3iby]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3iby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IBY FirstGlance]. <br>
<table><tr><td colspan='2'>[[3iby]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IBY FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3i8s|3i8s]], [[3i8x|3i8x]], [[3i92|3i92]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">feoB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iby OCA], [https://pdbe.org/3iby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iby RCSB], [https://www.ebi.ac.uk/pdbsum/3iby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iby ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iby OCA], [https://pdbe.org/3iby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iby RCSB], [https://www.ebi.ac.uk/pdbsum/3iby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iby ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FEOB_LEGPN FEOB_LEGPN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iby ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iby ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Prokaryotic pathogens have developed specialized mechanisms for efficient uptake of ferrous iron (Fe(2+)) from the host. In Legionella pneumophila, the causative agent of Legionnaires' disease, the transmembrane GTPase FeoB plays a key role in Fe(2+) acquisition and virulence. FeoB consists of a membrane-embedded core and an N-terminal, cytosolic region (NFeoB). Here, we report the crystal structure of NFeoB from L. pneumophila, revealing a monomeric protein comprising two separate domains with GTPase and guanine-nucleotide dissociation inhibitor (GDI) functions. The GDI domain displays a novel fold, whereas the overall structure of the GTPase domain resembles that of known G domains but is in the rarely observed nucleotide-free state.
Structure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of Legionella pneumophila.,Petermann N, Hansen G, Schmidt CL, Hilgenfeld R FEBS Lett. 2010 Feb 19;584(4):733-8. Epub 2009 Dec 27. PMID:20036663<ref>PMID:20036663</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3iby" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 33152]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hansen, G]]
[[Category: Legionella pneumophila]]
[[Category: Hilgenfeld, R]]
[[Category: Hansen G]]
[[Category: Petermann, N]]
[[Category: Hilgenfeld R]]
[[Category: Cell inner membrane]]
[[Category: Petermann N]]
[[Category: Cell membrane]]
[[Category: G domain]]
[[Category: G protein]]
[[Category: Gtp-binding]]
[[Category: Ion transport]]
[[Category: Iron]]
[[Category: Iron transport]]
[[Category: Iron uptake]]
[[Category: Membrane]]
[[Category: Nucleotide-binding]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Transport protein]]
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