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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j0p OCA], [https://pdbe.org/3j0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j0p RCSB], [https://www.ebi.ac.uk/pdbsum/3j0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j0p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j0p OCA], [https://pdbe.org/3j0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j0p RCSB], [https://www.ebi.ac.uk/pdbsum/3j0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j0p ProSAT]</span></td></tr>
</table>
</table>
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== Publication Abstract from PubMed ==
Although the structural core of the ribosome is conserved in all kingdoms of life, eukaryotic ribosomes are significantly larger and more complex than their bacterial counterparts. The extent to which these differences influence the molecular mechanism of translation remains elusive. Multiparticle cryo-electron microscopy and single-molecule FRET investigations of the mammalian pretranslocation complex reveal spontaneous, large-scale conformational changes, including an intersubunit rotation of the ribosomal subunits. Through structurally related processes, tRNA substrates oscillate between classical and at least two distinct hybrid configurations facilitated by localized changes in their L-shaped fold. Hybrid states are favored within the mammalian complex. However, classical tRNA positions can be restored by tRNA binding to the E site or by the eukaryotic-specific antibiotic and translocation inhibitor cycloheximide. These findings reveal critical distinctions in the structural and energetic features of bacterial and mammalian ribosomes, providing a mechanistic basis for divergent translation regulation strategies and species-specific antibiotic action.
Structure and dynamics of the Mammalian ribosomal pretranslocation complex.,Budkevich T, Giesebrecht J, Altman RB, Munro JB, Mielke T, Nierhaus KH, Blanchard SC, Spahn CM Mol Cell. 2011 Oct 21;44(2):214-24. PMID:22017870<ref>PMID:22017870</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3j0p" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
== References ==
<references/>
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Latest revision as of 10:09, 21 February 2024

Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1

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