3q7y: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3q7y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[3q7y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7Y FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jqz|1jqz]], [[3o4d|3o4d]], [[3q7w|3q7w]], [[3q7x|3q7x]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7y OCA], [https://pdbe.org/3q7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7y RCSB], [https://www.ebi.ac.uk/pdbsum/3q7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7y OCA], [https://pdbe.org/3q7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7y RCSB], [https://www.ebi.ac.uk/pdbsum/3q7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7y ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A compendium of different types of abiotic chemical syntheses identifies a consensus set of 10 "prebiotic" alpha-amino acids. Before the emergence of biosynthetic pathways, this set is the most plausible resource for protein formation (i.e., proteogenesis) within the overall process of abiogenesis. An essential unsolved question regarding this prebiotic set is whether it defines a "foldable set"-that is, does it contain sufficient chemical information to permit cooperatively folding polypeptides? If so, what (if any) characteristic properties might such polypeptides exhibit? To investigate these questions, two "primitive" versions of an extant protein fold (the beta-trefoil) were produced by top-down symmetric deconstruction, resulting in a reduced alphabet size of 12 or 13 amino acids and a percentage of prebiotic amino acids approaching 80%. These proteins show a substantial acidification of pI and require high salt concentrations for cooperative folding. The results suggest that the prebiotic amino acids do comprise a foldable set within the halophile environment.
Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein.,M Longo L, Lee J, Blaber M Proc Natl Acad Sci U S A. 2013 Jan 22. PMID:23341608<ref>PMID:23341608</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3q7y" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Blaber, M]]
[[Category: Blaber M]]
[[Category: Lee, J]]
[[Category: Lee J]]
[[Category: Beta-trefoil]]
[[Category: De novo protein]]

Latest revision as of 10:46, 21 February 2024

Crystal structure of K15R/E18D/Y22W/H41G/F44W/E51D/E53P/K57R/E60D/Y64W/H82G/F85W/E90D/E94P/K98R/E101D/Y108W/H129G/F132W/E137D Symfoil-4P: de novo designed beta-trefoil architecture with symmetric primary structure

3q7y, resolution 1.45Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=3q7y&oldid=4067660"