3qb8: Difference between revisions

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<StructureSection load='3qb8' size='340' side='right'caption='[[3qb8]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='3qb8' size='340' side='right'caption='[[3qb8]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qb8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QB8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qb8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paramecium_bursaria_Chlorella_virus_1 Paramecium bursaria Chlorella virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QB8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qb8 OCA], [https://pdbe.org/3qb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qb8 RCSB], [https://www.ebi.ac.uk/pdbsum/3qb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qb8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qb8 OCA], [https://pdbe.org/3qb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qb8 RCSB], [https://www.ebi.ac.uk/pdbsum/3qb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qb8 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/O41136_PBCV1 O41136_PBCV1]
Paramecium bursaria chlorella virus 1 (PBCV-1), a large DNA virus that infects green algae, encodes a histone H3 lysine 27-specific methyltransferase that functions in global transcriptional silencing of the host. PBCV-1 has another gene a654l that encodes a protein with sequence similarity to the GCN5 family histone acetyltransferases. In this study, we report a 1.5 A crystal structure of PBCV-1 A654L in a complex with coenzyme A. The structure reveals a unique feature of A654L that precludes its acetylation of histone peptide substrates. We demonstrate that A654L, hence named viral polyamine acetyltransferase (vPAT), acetylates polyamines such as putrescine, spermidine, cadaverine, and homospermidine present in both PBCV-1 and its host through a reaction dependent upon a conserved glutamate 27. Our study suggests that as the first virally encoded polyamine acetyltransferase, vPAT plays a possible key role in the regulation of polyamine catabolism in the host during viral replication.
 
Paramecium bursaria chlorella virus 1 encodes a polyamine acetyltransferase.,Charlop-Powers Z, Jakoncic J, Gurnon JR, Van Etten JL, Zhou MM J Biol Chem. 2012 Mar 16;287(12):9547-51. Epub 2012 Jan 25. PMID:22277659<ref>PMID:22277659</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3qb8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Charlop-Powers, Z]]
[[Category: Paramecium bursaria Chlorella virus 1]]
[[Category: Etten, J Van]]
[[Category: Charlop-Powers Z]]
[[Category: Gurnon, J]]
[[Category: Gurnon J]]
[[Category: Jakoncic, J]]
[[Category: Jakoncic J]]
[[Category: Zhou, M M]]
[[Category: Van Etten J]]
[[Category: Acetyltransferase]]
[[Category: Zhou M-M]]
[[Category: Coa]]
[[Category: Gnat n-acetyltransferase]]
[[Category: Spermidine]]
[[Category: Spermine]]
[[Category: Transferase]]

Latest revision as of 10:46, 21 February 2024

Paramecium Chlorella Bursaria Virus1 Putative ORF A654L is a Polyamine Acetyltransferase

3qb8, resolution 1.50Å

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