3qil: Difference between revisions

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<StructureSection load='3qil' size='340' side='right'caption='[[3qil]], [[Resolution|resolution]] 3.92&Aring;' scene=''>
<StructureSection load='3qil' size='340' side='right'caption='[[3qil]], [[Resolution|resolution]] 3.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qil]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QIL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qil]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QIL FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLTC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.92&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qil OCA], [https://pdbe.org/3qil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qil RCSB], [https://www.ebi.ac.uk/pdbsum/3qil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qil ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qil OCA], [https://pdbe.org/3qil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qil RCSB], [https://www.ebi.ac.uk/pdbsum/3qil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qil ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CLH1_BOVIN CLH1_BOVIN]] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.  
[https://www.uniprot.org/uniprot/CLH1_BOVIN CLH1_BOVIN] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Clathrin is a trimeric protein involved in receptor-mediated-endocytosis, but can function as a non-trimer outside of endocytosis. We have discovered that the subcellular distribution of a clathrin cysteine mutant we previously studied is altered and a proportion is also localized to nuclear spaces. MALS shows C1573A hub is a mixture of trimer-like and detrimerized molecules. The X-ray structure of the trimerization domain reveals that without light chains, a helix harboring cysteine-1573 is reoriented. We propose clathrin has a detrimerization switch, which suggests clathrin topology can be altered naturally for new functions.
 
Nuclear localization of clathrin involves a labile helix outside the trimerization domain.,Ybe JA, Fontaine SN, Stone T, Nix J, Lin X, Mishra S FEBS Lett. 2013 Jan 16;587(2):142-9. doi: 10.1016/j.febslet.2012.11.005. Epub, 2012 Nov 21. PMID:23178717<ref>PMID:23178717</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3qil" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Clathrin 3D structures|Clathrin 3D structures]]
*[[Clathrin 3D structures|Clathrin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bovin]]
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mishra, S]]
[[Category: Mishra S]]
[[Category: Nix, J]]
[[Category: Nix J]]
[[Category: Ybe, J A]]
[[Category: Ybe JA]]
[[Category: Clathrin trimerization domain]]
[[Category: Endocytosis]]
[[Category: Structural protein]]

Latest revision as of 10:48, 21 February 2024

Crystal structure analysis of the clathrin trimerization domain

3qil, resolution 3.92Å

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