3qwl: Difference between revisions
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<StructureSection load='3qwl' size='340' side='right'caption='[[3qwl]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='3qwl' size='340' side='right'caption='[[3qwl]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3qwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3qwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QWL FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwl OCA], [https://pdbe.org/3qwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwl RCSB], [https://www.ebi.ac.uk/pdbsum/3qwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwl ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwl OCA], [https://pdbe.org/3qwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwl RCSB], [https://www.ebi.ac.uk/pdbsum/3qwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/TBCD7_HUMAN TBCD7_HUMAN] Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.<ref>PMID:22795129</ref> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Guan | [[Category: Guan X]] | ||
[[Category: Landry | [[Category: Landry R]] | ||
[[Category: Park | [[Category: Park H]] | ||
[[Category: Tempel W]] | |||
[[Category: Tempel | [[Category: Tong Y]] | ||
[[Category: Tong | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Wernimont AK]] | ||
[[Category: Wernimont | |||
Latest revision as of 10:50, 21 February 2024
Crystal structure of human TBC1 domain family member 7
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