3p12: Difference between revisions

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<StructureSection load='3p12' size='340' side='right'caption='[[3p12]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='3p12' size='340' side='right'caption='[[3p12]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3p12]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staa8 Staa8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P12 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3p12]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_NCTC_8325 Staphylococcus aureus subsp. aureus NCTC 8325]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P12 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3p13|3p13]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rbsD, SAOUHSC_00240 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93061 STAA8])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p12 OCA], [https://pdbe.org/3p12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p12 RCSB], [https://www.ebi.ac.uk/pdbsum/3p12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p12 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p12 OCA], [https://pdbe.org/3p12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p12 RCSB], [https://www.ebi.ac.uk/pdbsum/3p12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p12 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RBSD_STAA8 RBSD_STAA8]] Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.[HAMAP-Rule:MF_01661]  
[https://www.uniprot.org/uniprot/RBSD_STAA8 RBSD_STAA8] Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.[HAMAP-Rule:MF_01661]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Ribose is transported into cells in its pyranose form and must be rearranged to its furanose form for further utilization. Ribose pyranase RbsD catalyzes the conversion of ribose from the pyranose to furanose form. This is the key step for substrate supply to ribokinase RbsK, which converts ribose to ribose-5-phosphate for further metabolism. Sequence analysis indicated Sa240 from Staphylococcus aureus was a ribose pyranase homolog. Here we showed that Sa240 formed dimeric structure both in solution and in crystal. S240-ribose complex structure showed a ribose binding site formed by an incomplete active site compared with RbsD. Because the catalytic activity of ribose pyranase depends on its oligomeric state, we propose Sa240 is catalytically inactive in its dimeric structure.
 
Crystal structure of Sa240: A ribose pyranase homolog with partial active site from Staphylococcus aureus.,Wang L, Wu M, Zang J J Struct Biol. 2011 May;174(2):413-9. Epub 2011 Jan 27. PMID:21276853<ref>PMID:21276853</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3p12" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Staa8]]
[[Category: Staphylococcus aureus subsp. aureus NCTC 8325]]
[[Category: Wang, L]]
[[Category: Wang L]]
[[Category: Wu, M]]
[[Category: Wu M]]
[[Category: Zang, J]]
[[Category: Zang J]]
[[Category: Carbohydrate metabolism]]
[[Category: D-ribose pyranase]]
[[Category: Isomerase]]
[[Category: Rbsd]]
[[Category: Sa240]]

Latest revision as of 11:20, 21 February 2024

Crystal Structure of D-ribose Pyranase Sa240

3p12, resolution 2.35Å

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