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<StructureSection load='5qst' size='340' side='right'caption='[[5qst]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
<StructureSection load='5qst' size='340' side='right'caption='[[5qst]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5qst]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QST FirstGlance]. <br>
<table><tr><td colspan='2'>[[5qst]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QST FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O3A:(3S)-N-methyl-N-phenylpyrrolidine-3-carboxamide'>O3A</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.58&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qst OCA], [http://pdbe.org/5qst PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qst RCSB], [http://www.ebi.ac.uk/pdbsum/5qst PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qst ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O3A:(3S)-N-methyl-N-phenylpyrrolidine-3-carboxamide'>O3A</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qst OCA], [https://pdbe.org/5qst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qst RCSB], [https://www.ebi.ac.uk/pdbsum/5qst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qst ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN]] STAG1-related intellectual disability-facial dysmorphism-gastroesophageal reflux syndrome. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN] STAG1-related intellectual disability-facial dysmorphism-gastroesophageal reflux syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN]] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.  
[https://www.uniprot.org/uniprot/STAG1_HUMAN STAG1_HUMAN] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Delft, F von]]
[[Category: Edwards A]]
[[Category: Edwards, A]]
[[Category: Gavard AE]]
[[Category: Gavard, A E]]
[[Category: Gileadi O]]
[[Category: Gileadi, O]]
[[Category: Katis VL]]
[[Category: Katis, V L]]
[[Category: Newman JA]]
[[Category: Newman, J A]]
[[Category: Von Delft F]]
[[Category: Pandda]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Transcription]]
[[Category: Xchemexplorer]]
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