Ubiquitin: Difference between revisions

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== Function ==

[[Ubiquitin]] (UBB) is found in almost all cells. It binds to proteins tagging them for destruction in the proteasome. UBB is activated by the UBB-activating enzymes E1, E2 and E3. UBB+1 is a frameshifted mutant of UBB observed in several diseases. A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule. '''Polyubiquitin''' (polyUBB) is a chain of ubiquitin molecules bound by peptide bonds. PolyUBB can be formed by lysine residues: K6, K11, K27, 29, K33, K48, and K63. Different lysine linkages convey different functions to polyUBB. Lys48- linked polyUBB is associated with proteasome degradation; Lys63-linked polyUBB is associated with non-proteolytic functions<ref>PMID:18438605</ref>. At least 4 UBB molecules are needed to tag a protein for the proteasome<ref>PMID:9759494</ref>. <scene name='41/417541/Cv/4'>Human ubiquitin interactions with ubiquitin-conjugating enzyme E2</scene> ([[3k9p]]). For details see<br />

[[Ubiquitin]] (UBB) is found in almost all cells. It binds to proteins tagging them for destruction in the proteasome. UBB is activated by the UBB-activating enzymes E1, E2 and E3. UBB+1 is a frameshifted mutant of UBB observed in several diseases. A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule. '''Polyubiquitin''' (polyUBB) is a chain of ubiquitin molecules bound by peptide bonds. PolyUBB can be formed by lysine residues: K6, K11, K27, 29, K33, K48, and K63. Different lysine linkages convey different functions to polyUBB. Lys48- linked polyUBB and LYs11-linked polyUBB are associated with proteasome degradation; Lys63-linked and Lys-6 polyUBB are associated with non-proteolytic functions<ref>PMID:18438605</ref>. At least 4 UBB molecules are needed to tag a protein for the proteasome<ref>PMID:9759494</ref>. <scene name='41/417541/Cv/4'>Human ubiquitin interactions with ubiquitin-conjugating enzyme E2</scene> ([[3k9p]]). For details see<br />

* [[Ubiquitin Structure & Function]]<br />

* [[Ubiquitin and Ubiquitination]]<br />

Ubiquitin: Difference between revisions

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 <StructureSection load='' size='340' side='right' caption='Human ubiquitin (green) complex with ubiquitin-conjugating enzyme E2 (deep sky blue), [[3k9p]]' scene='41/417541/Cv/3' >
 == Function ==
-[[Ubiquitin]] (UBB) is found in almost all cells.  It binds to proteins tagging them for destruction in the proteasome.  UBB is activated by the UBB-activating enzymes E1, E2 and E3.  UBB+1 is a frameshifted mutant of UBB observed in several diseases.  A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule.  '''Polyubiquitin''' (polyUBB) is a chain of ubiquitin molecules bound by peptide bonds.  PolyUBB can be formed by lysine residues: K6, K11, K27, 29, K33, K48, and K63.  Different lysine linkages convey different functions to polyUBB.  Lys48- linked polyUBB is associated with proteasome degradation; Lys63-linked polyUBB is associated with non-proteolytic functions<ref>PMID:18438605</ref>.  At least 4 UBB molecules are needed to tag a protein for the proteasome<ref>PMID:9759494</ref>. <scene name='41/417541/Cv/4'>Human ubiquitin interactions with ubiquitin-conjugating enzyme E2</scene> ([[3k9p]]). For details see<br />
+[[Ubiquitin]] (UBB) is found in almost all cells.  It binds to proteins tagging them for destruction in the proteasome.  UBB is activated by the UBB-activating enzymes E1, E2 and E3.  UBB+1 is a frameshifted mutant of UBB observed in several diseases.  A dimer of UBB (DiUBB) is formed by linkage of K48 to the C-terminus of a second UBB molecule.  '''Polyubiquitin''' (polyUBB) is a chain of ubiquitin molecules bound by peptide bonds.  PolyUBB can be formed by lysine residues: K6, K11, K27, 29, K33, K48, and K63.  Different lysine linkages convey different functions to polyUBB.  Lys48- linked polyUBB and LYs11-linked polyUBB are associated with proteasome degradation; Lys63-linked and Lys-6 polyUBB are associated with non-proteolytic functions<ref>PMID:18438605</ref>.  At least 4 UBB molecules are needed to tag a protein for the proteasome<ref>PMID:9759494</ref>. <scene name='41/417541/Cv/4'>Human ubiquitin interactions with ubiquitin-conjugating enzyme E2</scene> ([[3k9p]]). For details see<br />
 * [[Ubiquitin Structure & Function]]<br />
 * [[Ubiquitin and Ubiquitination]]<br />