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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[417d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=417D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=417D FirstGlance]. <br>
<table><tr><td colspan='2'>[[417d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=417D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=417D FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C46:6H,8H-3,4-DIHYDROPYRIMIDO[4,5-C][1,2]OXAZIN-7-0NE(CYTIDINE)-5-MONOPHOSPHATE'>C46</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C46:6H,8H-3,4-DIHYDROPYRIMIDO[4,5-C][1,2]OXAZIN-7-0NE(CYTIDINE)-5-MONOPHOSPHATE'>C46</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=417d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=417d OCA], [https://pdbe.org/417d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=417d RCSB], [https://www.ebi.ac.uk/pdbsum/417d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=417d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=417d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=417d OCA], [https://pdbe.org/417d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=417d RCSB], [https://www.ebi.ac.uk/pdbsum/417d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=417d ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The DNA hexamer d(CACGPG), in which dP is the ambivalent pyrimidine nucleoside analogue 2'-deoxy-beta-d-ribofuranosyl-(6H,8H-3, 4-dihydropyrimido[4,5-c][1,2]oxazin-7-one), crystallises as a left-handed Z-DNA duplex. X-ray analysis at 1.5 A shows that both P. A base-pairs are of the wobble type. This result appears inconsistent with other evidence from hybridisation and NMR studies of P-containing oligonucleotides, which suggests that, while P can form stable base-pairs with either A or G, thymine-like properties are more pronounced. Thermal denaturation experiments over a range of solution pH values indicate that protonation of the P.A base-pairs is unlikely to be responsible for the anomalous behaviour. No specific crystal packing effects can be identfied as an explanation, and it is concluded that base stacking and other interactions between nucleotide residues in Z-DNA are responsible.
A thymine-like base analogue forms wobble pairs with adenine in a Z-DNA duplex.,Schuerman GS, Van Meervelt L, Loakes D, Brown DM, Kong Thoo Lin P, Moore MH, Salisbury SA J Mol Biol. 1998 Oct 9;282(5):1005-11. PMID:9753550<ref>PMID:9753550</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 417d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Brown, D M]]
[[Category: Brown DM]]
[[Category: Lin, P K.T]]
[[Category: Lin PKT]]
[[Category: Loakes, D]]
[[Category: Loakes D]]
[[Category: Meervelt, L Van]]
[[Category: Moore GS]]
[[Category: Moore, G S]]
[[Category: Moore MH]]
[[Category: Moore, M H]]
[[Category: Schuerman MH]]
[[Category: Schuerman, M H]]
[[Category: Van Meervelt L]]
[[Category: Dna]]
[[Category: P a base-pair]]
[[Category: Pyrimidine analogue]]
[[Category: Z-dna]]
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