4ggn: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ggn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_knowlesi_strain_H Plasmodium knowlesi strain H] and [https://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GGN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ggn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_knowlesi_strain_H Plasmodium knowlesi strain H] and [https://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GGN FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ggn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ggn OCA], [https://pdbe.org/4ggn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ggn RCSB], [https://www.ebi.ac.uk/pdbsum/4ggn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ggn ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ggn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ggn OCA], [https://pdbe.org/4ggn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ggn RCSB], [https://www.ebi.ac.uk/pdbsum/4ggn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ggn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/A0A384KCF1_PLAKH A0A384KCF1_PLAKH]  
[https://www.uniprot.org/uniprot/A0A384KCF1_PLAKH A0A384KCF1_PLAKH]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Apicomplexan parasites enter host cells by many sophisticated steps including use of an ATP-powered invasion machinery. The machinery consists of multiple proteins, including a special myosin (MyoA) which moves along an actin fiber and which is connected to the myosin tail interaction protein (MTIP). Here we report a crystal structure of the major MyoA-binding domain (D3) of Plasmodium falciparum MTIP in complex with an anti-MTIP nanobody. In this complex, the MyoA-binding groove in MTIP-D3 is considerably less accessible than when occupied by the MyoA helix, due to a shift of two helices. The nanobody binds to an area slightly overlapping with the MyoA binding groove, covering a hydrophobic region next to the groove entrance. This provides a new avenue for arriving at compounds interfering with the invasion machinery since small molecules binding simultaneously to the nanobody binding site and the adjacent MyoA binding groove would prevent MyoA binding by MTIP.
The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody.,Khamrui S, Turley S, Pardon E, Steyaert J, Fan E, Verlinde CL, Bergman LW, Hol WG Mol Biochem Parasitol. 2013 Aug;190(2):87-91. doi:, 10.1016/j.molbiopara.2013.06.003. Epub 2013 Jul 4. PMID:23831371<ref>PMID:23831371</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ggn" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 11:30, 1 March 2024

Malaria invasion machinery protein complex

4ggn, resolution 2.29Å

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