4j2i: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4j2i]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J2I FirstGlance]. <br>
<table><tr><td colspan='2'>[[4j2i]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J2I FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j2i OCA], [https://pdbe.org/4j2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j2i RCSB], [https://www.ebi.ac.uk/pdbsum/4j2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j2i ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j2i OCA], [https://pdbe.org/4j2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j2i RCSB], [https://www.ebi.ac.uk/pdbsum/4j2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j2i ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In this work, we explore the influence of different solvents and ions on the crystallization behavior of an all-AT dodecamer d(AATAAATTTATT)2 In all cases, the oligonucleotides are found as continuous columns of stacked duplexes. The spatial organization of such columns is variable; consequently we have obtained seven different crystal forms. The duplexes can be made to crystallize in either parallel or crossed columns. Such versatility in the formation of a variety of crystal forms is characteristic for this sequence. It had not been previously reported for any other sequence. In all cases, the oligonucleotide duplexes have been found to crystallize in the B form. The crystallization conditions determine the organization of the crystal, although no clear local interactions have been detected. Mg(2+) and Ni(2+) can be used in order to obtain compact crossed structures. DNA-DNA interactions in the crystals of our all-AT duplexes present crossovers which are different from those previously reported for mixed sequence oligonucleotides. Our results demonstrate that changes in the ionic atmosphere and the crystallization solvent have a strong influence on the DNA-DNA interactions. Similar ionic changes will certainly influence the biological activity of DNA. Modulation of the crystal structure by ions should also be explored in DNA crystal engineering. Liquid crystals with a peculiar macroscopic shape have also been observed. (c) 2014 Wiley Periodicals, Inc. Biopolymers 103: 123-133, 2015.
Polymorphic crystal structures of an all-AT DNA dodecamer.,Acosta-Reyes FJ, Subirana JA, Pous J, Sanchez-Giraldo R, Condom N, Baldini R, Malinina L, Campos JL Biopolymers. 2015 Mar;103(3):123-33. doi: 10.1002/bip.22565. PMID:25257185<ref>PMID:25257185</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4j2i" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
</StructureSection>

Latest revision as of 12:00, 1 March 2024

Multiple crystal structures of an all-AT DNA dodecamer stabilized by weak interactions

4j2i, resolution 2.98Å

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