4k2j: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4k2j]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K2J FirstGlance]. <br>
<table><tr><td colspan='2'>[[4k2j]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K2J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k2j OCA], [https://pdbe.org/4k2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k2j RCSB], [https://www.ebi.ac.uk/pdbsum/4k2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k2j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k2j OCA], [https://pdbe.org/4k2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k2j RCSB], [https://www.ebi.ac.uk/pdbsum/4k2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k2j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/Q9DUN0_HHV8 Q9DUN0_HHV8]  
[https://www.uniprot.org/uniprot/Q9DUN0_HHV8 Q9DUN0_HHV8]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
LANA is the KSHV-encoded terminal repeat binding protein essential for viral replication and episome maintenance during latency. We have determined the X-ray crystal structure of LANA C-terminal DNA binding domain (LANADBD) to reveal its capacity to form a decameric ring with an exterior DNA binding surface. The dimeric core is structurally similar to EBV EBNA1 with an N-terminal arm that regulates DNA binding and is required for replication function. The oligomeric interface between LANA dimers is dispensable for single site DNA binding, but is required for cooperative DNA binding, replication function, and episome maintenance. We also identify a basic patch opposite of the DNA binding surface that is responsible for the interaction with BRD proteins and contributes to episome maintenance function. The structural features of LANADBD suggest a novel mechanism of episome maintenance through DNA-binding induced oligomeric assembly.
Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANA.,Domsic JF, Chen HS, Lu F, Marmorstein R, Lieberman PM PLoS Pathog. 2013 Oct;9(10):e1003672. doi: 10.1371/journal.ppat.1003672. Epub, 2013 Oct 17. PMID:24146617<ref>PMID:24146617</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4k2j" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 12:08, 1 March 2024

Decameric ring structure of KSHV (HHV-8) latency-associated nuclear antigen (LANA) DNA binding domain

4k2j, resolution 2.05Å

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