4n0l: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4n0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanopyrus_kandleri_AV19 Methanopyrus kandleri AV19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N0L FirstGlance]. <br>
<table><tr><td colspan='2'>[[4n0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanopyrus_kandleri_AV19 Methanopyrus kandleri AV19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N0L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n0l OCA], [https://pdbe.org/4n0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n0l RCSB], [https://www.ebi.ac.uk/pdbsum/4n0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n0l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n0l OCA], [https://pdbe.org/4n0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n0l RCSB], [https://www.ebi.ac.uk/pdbsum/4n0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n0l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/Q8TVS2_METKA Q8TVS2_METKA]  
[https://www.uniprot.org/uniprot/Q8TVS2_METKA Q8TVS2_METKA]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The prokaryotic adaptive immune system is based on the incorporation of genome fragments of invading viral genetic elements into clusters of regulatory interspaced short palindromic repeats (CRISPRs). The CRISPR loci are transcribed and processed into crRNAs, which are then used to target the invading nucleic acid for degradation. The large family of CRISPR-associated (Cas) proteins mediates this interference response. We have characterized Methanopyrus kandleri Csm3, a protein of the type III-A CRISPR-Cas complex. The 2.4 A resolution crystal structure shows an elaborate four-domain fold organized around a core RRM-like domain. The overall architecture highlights the structural homology to Cas7, the Cas protein that forms the backbone of type I interference complexes. Csm3 binds unstructured RNAs in a sequence non-specific manner, suggesting that it interacts with the variable spacer sequence of the crRNA. The structural and biochemical data provide insights into the similarities and differences in this group of Cas proteins.
Structure and RNA-binding properties of the Type III-A CRISPR-associated protein Csm3.,Hrle A, Su AA, Ebert J, Benda C, Randau L, Conti E RNA Biol. 2013 Sep 30;10(11). PMID:24157656<ref>PMID:24157656</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4n0l" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 12:30, 1 March 2024

Methanopyrus kandleri Csm3 crystal structure

4n0l, resolution 2.37Å

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