4q7m: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4q7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q7M FirstGlance]. <br>
<table><tr><td colspan='2'>[[4q7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q7M FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7m OCA], [https://pdbe.org/4q7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q7m RCSB], [https://www.ebi.ac.uk/pdbsum/4q7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q7m ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7m OCA], [https://pdbe.org/4q7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q7m RCSB], [https://www.ebi.ac.uk/pdbsum/4q7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q7m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/Y288_THEMA Y288_THEMA]  
[https://www.uniprot.org/uniprot/Y288_THEMA Y288_THEMA]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
ABC exporters are ubiquitous multidomain transport proteins that couple ATP hydrolysis at a pair of nucleotide binding domains to substrate transport across the lipid bilayer mediated by two transmembrane domains. Recently, the crystal structure of the heterodimeric ABC exporter TM287/288 was determined. One of its asymmetric ATP binding sites is called the degenerate site; it binds nucleotides tightly but is impaired in terms of ATP hydrolysis. Here we report the crystal structures of both isolated motor domains of TM287/288. Unexpectedly, structural elements constituting the degenerate ATP binding site are disordered in these crystals and become structured only in the context of the full-length transporter. In addition, hydrogen bonding patterns of key residues, including those of the catalytically important Walker B and the switch loop motifs, are fundamentally different in the solitary NBDs compared to those in the intact transport protein. The structures reveal crucial interdomain contacts that need to be established for the proper assembly of the functional transporter complex.
A Transporter Motor Taken Apart: Flexibility in the Nucleotide Binding Domains of a Heterodimeric ABC Exporter.,Bukowska MA, Hohl M, Geertsma ER, Hurlimann LM, Grutter MG, Seeger MA Biochemistry. 2015 May 19;54(19):3086-99. doi: 10.1021/acs.biochem.5b00188. Epub , 2015 May 7. PMID:25947941<ref>PMID:25947941</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4q7m" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 12:44, 1 March 2024

Structure of NBD288-Avi of TM287/288

4q7m, resolution 2.30Å

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