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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4rih]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cyanogenus Streptomyces cyanogenus] and [https://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RIH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4rih]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cyanogenus Streptomyces cyanogenus] and [https://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RIH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3R2:2-DEOXY-5-O-[(R)-{[(R)-{[(1S,3R,4R,5S)-3,4-DIHYDROXY-5-METHYLCYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]-3,4-DIHYDROTHYMIDINE'>3R2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3R2:2-DEOXY-5-O-[(R)-{[(R)-{[(1S,3R,4R,5S)-3,4-DIHYDROXY-5-METHYLCYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]-3,4-DIHYDROTHYMIDINE'>3R2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rih OCA], [https://pdbe.org/4rih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rih RCSB], [https://www.ebi.ac.uk/pdbsum/4rih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rih ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rih OCA], [https://pdbe.org/4rih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rih RCSB], [https://www.ebi.ac.uk/pdbsum/4rih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rih ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/Q9ZGC0_STRCY Q9ZGC0_STRCY] [https://www.uniprot.org/uniprot/Q9RPA7_STRFR Q9RPA7_STRFR]  
[https://www.uniprot.org/uniprot/Q9ZGC0_STRCY Q9ZGC0_STRCY] [https://www.uniprot.org/uniprot/Q9RPA7_STRFR Q9RPA7_STRFR]  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structures of the O-glycosyltransferase LanGT2 and the engineered, CC bond-forming variant LanGT2S8Ac show how the replacement of a single loop can change the functionality of the enzyme. Crystal structures of the enzymes in complex with a nonhydrolyzable nucleotide-sugar analogue revealed that there is a conformational transition to create the binding sites for the aglycon substrate. This induced-fit transition was explored by molecular docking experiments with various aglycon substrates.
Structural Characterization of O- and C-Glycosylating Variants of the Landomycin Glycosyltransferase LanGT2.,Tam HK, Harle J, Gerhardt S, Rohr J, Wang G, Thorson JS, Bigot A, Lutterbeck M, Seiche W, Breit B, Bechthold A, Einsle O Angew Chem Int Ed Engl. 2015 Jan 7. doi: 10.1002/anie.201409792. PMID:25581707<ref>PMID:25581707</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4rih" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 12:52, 1 March 2024

Chimeric Glycosyltransferase LanGT2S8Ac, carbasugar substrate complex

4rih, resolution 2.22Å

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