8j72: Difference between revisions

Latest revision as of 12:06, 6 March 2024

Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1

Structural highlights

8j72 is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.16Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LIN41_MOUSE E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (PubMed:19898466). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression (PubMed:22735451). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (PubMed:22735451). Specific regulator of miRNA biogenesis. miRNA Binds MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity).[UniProtKB:Q2Q1W2]^[1] ^[2] ^[3]

References

↑ Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG. The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009 Dec;11(12):1411-20. PMID:19898466 doi:10.1038/ncb1987
↑ Chang HM, Martinez NJ, Thornton JE, Hagan JP, Nguyen KD, Gregory RI. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012 Jun 26;3:923. PMID:22735451 doi:10.1038/ncomms1909
↑ Loedige I, Gaidatzis D, Sack R, Meister G, Filipowicz W. The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. Nucleic Acids Res. 2013 Jan 7;41(1):518-32. doi: 10.1093/nar/gks1032. Epub 2012 , Nov 3. PMID:23125361 doi:https://dx.doi.org/10.1093/nar/gks1032

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OCA

[1] Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG. The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009 Dec;11(12):1411-20. PMID:19898466 doi:10.1038/ncb1987

[2] Chang HM, Martinez NJ, Thornton JE, Hagan JP, Nguyen KD, Gregory RI. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012 Jun 26;3:923. PMID:22735451 doi:10.1038/ncomms1909

[3] Loedige I, Gaidatzis D, Sack R, Meister G, Filipowicz W. The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. Nucleic Acids Res. 2013 Jan 7;41(1):518-32. doi: 10.1093/nar/gks1032. Epub 2012 , Nov 3. PMID:23125361 doi:https://dx.doi.org/10.1093/nar/gks1032

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[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8j72 is ON HOLD  until Paper Publication
+==Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1==
+<StructureSection load='8j72' size='340' side='right'caption='[[8j72]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
-Authors: Shi, F.D., Zhang, K., Che, S.Y., Zhi, S.X., Yang, N.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8j72]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J72 FirstGlance]. <br>
-Description: Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.16&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j72 OCA], [https://pdbe.org/8j72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j72 RCSB], [https://www.ebi.ac.uk/pdbsum/8j72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j72 ProSAT]</span></td></tr>
-[[Category: Shi, F.D]]
+</table>
-[[Category: Che, S.Y]]
+== Function ==
-[[Category: Zhang, K]]
+[https://www.uniprot.org/uniprot/LIN41_MOUSE LIN41_MOUSE] E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (PubMed:19898466). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression (PubMed:22735451). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (PubMed:22735451). Specific regulator of miRNA biogenesis. miRNA Binds MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity).[UniProtKB:Q2Q1W2]<ref>PMID:19898466</ref> <ref>PMID:22735451</ref> <ref>PMID:23125361</ref>
-[[Category: Yang, N]]
+== References ==
-[[Category: Zhi, S.X]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Che SY]]
+[[Category: Shi FD]]
+[[Category: Yang N]]
+[[Category: Zhang K]]
+[[Category: Zhi SX]]

8j72: Difference between revisions

Latest revision as of 12:06, 6 March 2024

Crystal structure of mammalian Trim71 in complex with lncRNA Trincr1

Structural highlights

Function

References

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