8tka: Difference between revisions

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'''Unreleased structure'''


The entry 8tka is ON HOLD  until Paper Publication
==Structure of Orthoreovirus RNA Chaperone SigmaNS R6A mutant==
 
<StructureSection load='8tka' size='340' side='right'caption='[[8tka]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
Authors: Prasad, B.V.V., Zhao, B., Hu, L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8tka]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1 Mammalian orthoreovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TKA FirstGlance]. <br>
Description: Structure of Orthoreovirus RNA Chaperone SigmaNS R6A mutant
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
[[Category: Hu, L]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tka OCA], [https://pdbe.org/8tka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tka RCSB], [https://www.ebi.ac.uk/pdbsum/8tka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tka ProSAT]</span></td></tr>
[[Category: Zhao, B]]
</table>
[[Category: Prasad, B.V.V]]
== Function ==
[https://www.uniprot.org/uniprot/SIGNS_REOVD SIGNS_REOVD] Protein that binds to ssRNA and participates with protein mu-NS in forming the matrix of viral factories, which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place (PubMed:11152519). Plays a role in the inhibition of the integrated stress response (ISR) to escape from host cell translational shutoff (PubMed:28794026). Participates in the disruption of stress granules (SG) through its association with host G3BP1 and mu-NS (PubMed:28794026).<ref>PMID:11152519</ref> <ref>PMID:28794026</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mammalian orthoreovirus 1]]
[[Category: Hu L]]
[[Category: Prasad BVV]]
[[Category: Zhao B]]
Retrieved from "https://proteopedia.org/8tka"