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<StructureSection load='5ttj' size='340' side='right'caption='[[5ttj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5ttj' size='340' side='right'caption='[[5ttj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ttj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Psep6 Psep6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TTJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ttj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida_S16 Pseudomonas putida S16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TTJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ttk|5ttk]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPS_4081 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1042876 PSEP6])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [https://pdbe.org/5ttj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [https://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ttj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ttj OCA], [http://pdbe.org/5ttj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ttj RCSB], [http://www.ebi.ac.uk/pdbsum/5ttj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ttj ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/F8G0P2_PSEP6 F8G0P2_PSEP6]
The first structure of nicotine oxidoreductase (NicA2) was determined by X-ray crystallography. Pseudomonas putida has evolved nicotine-degrading activity to provide a source of carbon and nitrogen. The structure establishes NicA2 as a member of the monoamine oxidase family. Residues 1-50 are disordered and may play a role in localization. The nicotine-binding site proximal to the isoalloxazine ring of flavin shows an unusual composition of the classical aromatic cage (W427 and N462). The active site architecture is consistent with the proposed binding of the deprotonated form of the substrate and the flavin-dependent oxidation of the pyrrolidone C-N bond followed by nonenzymatic hydrolysis.
 
Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida.,Tararina MA, Janda KD, Allen KN Biochemistry. 2016 Dec 6;55(48):6595-6598. Epub 2016 Nov 18. PMID:27933790<ref>PMID:27933790</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5ttj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Psep6]]
[[Category: Pseudomonas putida S16]]
[[Category: Allen, K N]]
[[Category: Allen KN]]
[[Category: Janda, K D]]
[[Category: Janda KD]]
[[Category: Tararina, M A]]
[[Category: Tararina MA]]
[[Category: Flavoenzyme]]
[[Category: Monoamine oxidase family]]
[[Category: Nicotine degradation]]
[[Category: Oxidoreductase]]
[[Category: Phbh fold]]

Latest revision as of 14:23, 6 March 2024

Crystal Structure of Nicotine Oxidoreductase from Pseudomonas putida

5ttj, resolution 2.20Å

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