6vcc: Difference between revisions
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==Cryo-EM structure of the Dvl2 DIX filament== | ==Cryo-EM structure of the Dvl2 DIX filament== | ||
<StructureSection load='6vcc' size='340' side='right'caption='[[6vcc]]' scene=''> | <StructureSection load='6vcc' size='340' side='right'caption='[[6vcc]], [[Resolution|resolution]] 3.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VCC OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6vcc]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VCC FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vcc OCA], [https://pdbe.org/6vcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vcc RCSB], [https://www.ebi.ac.uk/pdbsum/6vcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vcc ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DVL2_MOUSE DVL2_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes.<ref>PMID:17199046</ref> <ref>PMID:21189423</ref> <ref>PMID:20947020</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | |||
[[Category: Chen DH]] | [[Category: Chen DH]] | ||
[[Category: Enos M]] | [[Category: Enos M]] | ||
Latest revision as of 14:37, 6 March 2024
Cryo-EM structure of the Dvl2 DIX filament
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