6vp9: Difference between revisions

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====
==Cryo-EM structure of human NatB complex==
<StructureSection load='6vp9' size='340' side='right'caption='[[6vp9]]' scene=''>
<StructureSection load='6vp9' size='340' side='right'caption='[[6vp9]], [[Resolution|resolution]] 3.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
<table><tr><td colspan='2'>[[6vp9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VP9 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vp9 OCA], [http://pdbe.org/6vp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vp9 RCSB], [http://www.ebi.ac.uk/pdbsum/6vp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vp9 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.46&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMC:CARBOXYMETHYL+COENZYME+*A'>CMC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vp9 OCA], [https://pdbe.org/6vp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vp9 RCSB], [https://www.ebi.ac.uk/pdbsum/6vp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vp9 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NAA20_HUMAN NAA20_HUMAN] Autosomal recessive non-syndromic intellectual disability. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NAA20_HUMAN NAA20_HUMAN] Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln (PubMed:34230638). Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.<ref>PMID:18570629</ref> <ref>PMID:34230638</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Z-disk]]
[[Category: Deng S]]
[[Category: Marmorstein R]]
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