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<StructureSection load='6xss' size='340' side='right'caption='[[6xss]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<StructureSection load='6xss' size='340' side='right'caption='[[6xss]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6xss]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XSS FirstGlance]. <br>
<table><tr><td colspan='2'>[[6xss]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XSS FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xss OCA], [https://pdbe.org/6xss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xss RCSB], [https://www.ebi.ac.uk/pdbsum/6xss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xss ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xss OCA], [https://pdbe.org/6xss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xss RCSB], [https://www.ebi.ac.uk/pdbsum/6xss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xss ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A systematic and robust approach to generating complex protein nanomaterials would have broad utility. We develop a hierarchical approach to designing multi-component protein assemblies from two classes of modular building blocks: designed helical repeat proteins (DHRs) and helical bundle oligomers (HBs). We first rigidly fuse DHRs to HBs to generate a large library of oligomeric building blocks. We then generate assemblies with cyclic, dihedral, and point group symmetries from these building blocks using architecture guided rigid helical fusion with new software named WORMS. X-ray crystallography and cryo-electron microscopy characterization show that the hierarchical design approach can accurately generate a wide range of assemblies, including a 43 nm diameter icosahedral nanocage. The computational methods and building block sets described here provide a very general route to de novo designed protein nanomaterials.
Design of multi-scale protein complexes by hierarchical building block fusion.,Hsia Y, Mout R, Sheffler W, Edman NI, Vulovic I, Park YJ, Redler RL, Bick MJ, Bera AK, Courbet A, Kang A, Brunette TJ, Nattermann U, Tsai E, Saleem A, Chow CM, Ekiert D, Bhabha G, Veesler D, Baker D Nat Commun. 2021 Apr 16;12(1):2294. doi: 10.1038/s41467-021-22276-z. PMID:33863889<ref>PMID:33863889</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6xss" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Synthetic construct sequences]]
[[Category: Synthetic construct]]
[[Category: Baker, D]]
[[Category: Baker D]]
[[Category: Bhabha, G]]
[[Category: Bhabha G]]
[[Category: Edman, N I]]
[[Category: Edman NI]]
[[Category: Ekiert, D]]
[[Category: Ekiert D]]
[[Category: Redler, R L]]
[[Category: Redler RL]]
[[Category: De novo protein]]
[[Category: Helical bundle]]
[[Category: Helical repeat]]

Latest revision as of 14:51, 6 March 2024

CryoEM structure of designed helical fusion protein C4_nat_HFuse-7900

6xss, resolution 3.70Å

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