7jju: Difference between revisions

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<StructureSection load='7jju' size='340' side='right'caption='[[7jju]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='7jju' size='340' side='right'caption='[[7jju]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7jju]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JJU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JJU FirstGlance]. <br>
<table><tr><td colspan='2'>[[7jju]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Potato_leafroll_virus Potato leafroll virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JJU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GZ6:Guanidinium'>GZ6</scene>, <scene name='pdbligand=IRI:IRIDIUM+HEXAMMINE+ION'>IRI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.604&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=U23:'>U23</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=GZ6:Guanidinium'>GZ6</scene>, <scene name='pdbligand=IRI:IRIDIUM+HEXAMMINE+ION'>IRI</scene>, <scene name='pdbligand=U23:URIDINE-5-MONOPHOSPHATE-2,3-CYCLIC+PHOSPHATE'>U23</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jju OCA], [http://pdbe.org/7jju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jju RCSB], [http://www.ebi.ac.uk/pdbsum/7jju PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jju ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jju OCA], [https://pdbe.org/7jju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jju RCSB], [https://www.ebi.ac.uk/pdbsum/7jju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jju ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Exoribonuclease-resistant RNAs (xrRNAs) are discrete elements that block the progression of 5' to 3' exoribonucleases using specifically folded RNA structures. A recently discovered class of xrRNA is widespread in several genera of plant-infecting viruses, within both noncoding and protein-coding subgenomic RNAs. The structure of one such xrRNA from a dianthovirus revealed three-dimensional details of the resistant fold but did not answer all questions regarding the conservation and diversity of this xrRNA class. Here, we present the crystal structure of a representative polerovirus xrRNA that contains sequence elements that diverge from the previously solved structure. This new structure rationalizes previously unexplained sequence conservation patterns and shows interactions not present in the first structure. Together, the structures of these xrRNAs from dianthovirus and polerovirus genera support the idea that these plant virus xrRNAs fold through a defined pathway that includes a programmed intermediate conformation. This work deepens our knowledge of the structure-function relationship of xrRNAs and shows how evolution can craft similar RNA folds from divergent sequences.
The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold.,Steckelberg AL, Vicens Q, Costantino DA, Nix JC, Kieft JS RNA. 2020 Aug 26. pii: rna.076224.120. doi: 10.1261/rna.076224.120. PMID:32848042<ref>PMID:32848042</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7jju" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Auffinger, P]]
[[Category: Potato leafroll virus]]
[[Category: Costantino, D C]]
[[Category: Auffinger P]]
[[Category: Kieft, J S]]
[[Category: Costantino DC]]
[[Category: Nix, J C]]
[[Category: Kieft JS]]
[[Category: Steckelberg, A L]]
[[Category: Nix JC]]
[[Category: Vicens, Q]]
[[Category: Steckelberg A-L]]
[[Category: Rna]]
[[Category: Vicens Q]]
[[Category: Rna structure viral rna exonuclease resistance rna pseudoknot polerovirus plant virus]]
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