7k3r: Difference between revisions
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==Cryo-EM structure of AIM2-PYD filament== | ==Cryo-EM structure of AIM2-PYD filament== | ||
<StructureSection load='7k3r' size='340' side='right'caption='[[7k3r]]' scene=''> | <StructureSection load='7k3r' size='340' side='right'caption='[[7k3r]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K3R FirstGlance]. <br> | <table><tr><td colspan='2'>[[7k3r]] is a 21 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K3R FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k3r OCA], [https://pdbe.org/7k3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k3r RCSB], [https://www.ebi.ac.uk/pdbsum/7k3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k3r ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k3r OCA], [https://pdbe.org/7k3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k3r RCSB], [https://www.ebi.ac.uk/pdbsum/7k3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k3r ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/AIM2_HUMAN AIM2_HUMAN] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.<ref>PMID:16432157</ref> <ref>PMID:17726700</ref> <ref>PMID:19158679</ref> <ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:20566831</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Egelman EH]] | [[Category: Egelman EH]] | ||
