7kci: Difference between revisions

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<StructureSection load='7kci' size='340' side='right'caption='[[7kci]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='7kci' size='340' side='right'caption='[[7kci]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7kci]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KCI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7KCI FirstGlance]. <br>
<table><tr><td colspan='2'>[[7kci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KCI FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7kci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kci OCA], [http://pdbe.org/7kci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7kci RCSB], [http://www.ebi.ac.uk/pdbsum/7kci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7kci ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kci OCA], [https://pdbe.org/7kci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kci RCSB], [https://www.ebi.ac.uk/pdbsum/7kci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kci ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
On the basis of the crystal structure of the trp repressor/operator complex, it has been proposed that the specificity of the interaction can be explained not only by direct hydrogen bonding and non-polar contacts between the protein and the bases of its target DNA, but also by indirect structural effects and water-mediated interactions. To understand the contribution of DNA structure and hydration in this context, the structure of the free DNA must be compared with its structure when complexed with the protein. Here we present the high-resolution crystal structure of the trp operator region that is most important in the recognition process. By comparing the free and bound states of the DNA regulatory sequence, we show that the structure and hydration of the DNA target are important elements in its recognition by the repressor protein.
Determinants of repressor/operator recognition from the structure of the trp operator binding site.,Shakked Z, Guzikevich-Guerstein G, Frolow F, Rabinovich D, Joachimiak A, Sigler PB Nature. 1994 Mar 31;368(6470):469-73. doi: 10.1038/368469a0. PMID:8133895<ref>PMID:8133895</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7kci" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Frolow, F]]
[[Category: Synthetic construct]]
[[Category: Guzikevich-Guerstein, G]]
[[Category: Frolow F]]
[[Category: Joachimiak, A]]
[[Category: Guzikevich-Guerstein G]]
[[Category: Rabinovich, D]]
[[Category: Joachimiak A]]
[[Category: Shakked, Z]]
[[Category: Rabinovich D]]
[[Category: Sigler, P B]]
[[Category: Shakked Z]]
[[Category: B-dna]]
[[Category: Sigler PB]]
[[Category: Deoxyribonucleic acid]]
[[Category: Dna]]
[[Category: Double helix]]

Latest revision as of 14:56, 6 March 2024

DETERMINANTS OF REPRESSOR/OPERATOR RECOGNITION FROM THE STRUCTURE OF THE TRP OPERATOR BINDING SITE

7kci, resolution 1.95Å

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