1wsp: Difference between revisions
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<StructureSection load='1wsp' size='340' side='right'caption='[[1wsp]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='1wsp' size='340' side='right'caption='[[1wsp]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1wsp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1wsp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WSP FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsp OCA], [https://pdbe.org/1wsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wsp RCSB], [https://www.ebi.ac.uk/pdbsum/1wsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsp OCA], [https://pdbe.org/1wsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wsp RCSB], [https://www.ebi.ac.uk/pdbsum/1wsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wsp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/AXIN1_RAT AXIN1_RAT] Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. Also facilitates the phosphorylation of APC by GSK3B. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hanamura | [[Category: Rattus norvegicus]] | ||
[[Category: Higuchi | [[Category: Hanamura T]] | ||
[[Category: Kikuchi | [[Category: Higuchi Y]] | ||
[[Category: Shibata | [[Category: Kikuchi A]] | ||
[[Category: Ueda | [[Category: Shibata N]] | ||
[[Category: Yamamoto | [[Category: Ueda Y]] | ||
[[Category: Yamamoto | [[Category: Yamamoto H]] | ||
[[Category: Yamamoto R]] | |||
