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| == Function == | | == Function == |
| [https://www.uniprot.org/uniprot/Q4QRE8_DANRE Q4QRE8_DANRE] | | [https://www.uniprot.org/uniprot/Q4QRE8_DANRE Q4QRE8_DANRE] |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Nanos is an RNA-binding protein that is involved in the development and maintenance of germ cells. In combination with Pumilio, Nanos binds to the 3' untranslated region of a messenger RNA and represses its translation. Nanos has two conserved Cys-Cys-His-Cys zinc-finger motifs that are indispensable for its function. In this study, we have determined the crystal structure of the zinc-finger domain of zebrafish Nanos, for the first time revealing that Nanos adopts a novel zinc-finger structure. In addition, Nanos has a conserved basic surface that is directly involved in RNA binding. Our results provide the structural basis for further studies to clarify Nanos function.
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| Crystal structure of zinc-finger domain of Nanos and its functional implications.,Hashimoto H, Hara K, Hishiki A, Kawaguchi S, Shichijo N, Nakamura K, Unzai S, Tamaru Y, Shimizu T, Sato M EMBO Rep. 2010 Nov;11(11):848-53. Epub 2010 Oct 15. PMID:20948543<ref>PMID:20948543</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 3alr" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
