5vrq: Difference between revisions

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<StructureSection load='5vrq' size='340' side='right'caption='[[5vrq]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
<StructureSection load='5vrq' size='340' side='right'caption='[[5vrq]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5vrq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VRQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5vrq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VRQ FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">legA12, lpg0483 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.205&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vrq OCA], [http://pdbe.org/5vrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vrq RCSB], [http://www.ebi.ac.uk/pdbsum/5vrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vrq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vrq OCA], [https://pdbe.org/5vrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vrq RCSB], [https://www.ebi.ac.uk/pdbsum/5vrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vrq ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q5ZY89_LEGPH Q5ZY89_LEGPH]
Legionella pneumophila is a pathogen, causing severe pneumonia in humans called Legionnaires' disease. AnkC (LegA12) is a poorly characterized 495-residue effector protein conserved in multiple Legionella species. Here, we report the crystal structure of a C-terminally truncated AnkC (2-384) at 3.2 A resolution. The structure shows seven ankyrin repeats (ARs) with unique structural features. AnkC forms a dimer along the outer surface of loops between ARs. The dimer exists both in the crystal form and in solution, as shown by analytical ultracentrifugation. This is the first example of ARs as a dimerization module as opposed to solely a protein interaction domain. In addition, a novel alpha-helix insert between AR3-AR4 is positioned across the surface opposite the ankyrin groove. Sequence conservation suggests that the ankyrin groove of AnkC is a functional site that interacts with binding targets. This ankyrin domain structure is an important step towards a functional characterization of AnkC.
 
Ankyrin repeats as a dimerization module.,Kozlov G, Wong K, Wang W, Skubak P, Munoz-Escobar J, Liu Y, Siddiqui N, Pannu NS, Gehring K Biochem Biophys Res Commun. 2017 Nov 21. pii: S0006-291X(17)32314-8. doi:, 10.1016/j.bbrc.2017.11.135. PMID:29175332<ref>PMID:29175332</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5vrq" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Legph]]
[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
[[Category: Structural genomic]]
[[Category: Gehring K]]
[[Category: Gehring, K]]
[[Category: Kozlov G]]
[[Category: Kozlov, G]]
[[Category: Liu Y]]
[[Category: Liu, Y]]
[[Category: Munoz-Escobar J]]
[[Category: Munoz-Escobar, J]]
[[Category: Pannu NS]]
[[Category: Pannu, N S]]
[[Category: Skubak P]]
[[Category: Skubak, P]]
[[Category: Wang W]]
[[Category: Wang, W]]
[[Category: Wong K]]
[[Category: Wong, K]]
[[Category: Ankyrin repeat]]
[[Category: Bacterial effector]]
[[Category: Bsgi]]
[[Category: Legionella]]
[[Category: Protein binding]]

Latest revision as of 14:12, 13 March 2024

Crystal structure of Legionella pneumophila effector AnkC

5vrq, resolution 3.21Å

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