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| Line 3: |
Line 3: |
| <SX load='6bpq' size='340' side='right' viewer='molstar' caption='[[6bpq]], [[Resolution|resolution]] 4.10Å' scene=''> | | <SX load='6bpq' size='340' side='right' viewer='molstar' caption='[[6bpq]], [[Resolution|resolution]] 4.10Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[6bpq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Collared_flycatcher Collared flycatcher]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6BPQ FirstGlance]. <br> | | <table><tr><td colspan='2'>[[6bpq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ficedula_albicollis Ficedula albicollis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BPQ FirstGlance]. <br> |
| </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1Å</td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRPM8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=59894 Collared flycatcher])</td></tr>
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpq OCA], [https://pdbe.org/6bpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bpq RCSB], [https://www.ebi.ac.uk/pdbsum/6bpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpq ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6bpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpq OCA], [http://pdbe.org/6bpq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bpq RCSB], [http://www.ebi.ac.uk/pdbsum/6bpq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpq ProSAT]</span></td></tr> | |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
| | == Function == |
| == Publication Abstract from PubMed == | | [https://www.uniprot.org/uniprot/U3JD03_FICAL U3JD03_FICAL] |
| Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that are involved in a variety of physiological processes. Within the TRPM family, member 8 (TRPM8) is the primary cold- and menthol-sensor in humans. We determined the cryo-electron microscopy structure of the full-length TRPM8 from the collared flycatcher at an overall resolution of ~4.1 A. Our TRPM8 structure reveals a three-layered architecture. The amino-terminal domain with a fold distinct among known TRP structures, together with the carboxyl-terminal region, forms a large two-layered cytosolic ring that extensively interacts with the transmembrane channel layer. The structure suggests that the menthol binding site is located within the voltage-sensor-like domain and thus provides a structural glimpse of the design principle of the molecular transducer for cold and menthol sensation.
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| | |
| Structure of the cold- and menthol-sensing ion channel TRPM8.,Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee SY Science. 2017 Dec 7. pii: science.aan4325. doi: 10.1126/science.aan4325. PMID:29217583<ref>PMID:29217583</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
| |
| <div class="pdbe-citations 6bpq" style="background-color:#fffaf0;"></div>
| |
| == References ==
| |
| <references/>
| |
| __TOC__ | | __TOC__ |
| </SX> | | </SX> |
| [[Category: Collared flycatcher]] | | [[Category: Ficedula albicollis]] |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Borschel, W F]] | | [[Category: Borschel WF]] |
| [[Category: Lander, G C]] | | [[Category: Lander GC]] |
| [[Category: Lee, S Y]] | | [[Category: Lee S-Y]] |
| [[Category: Wu, M]] | | [[Category: Wu M]] |
| [[Category: Yin, Y]] | | [[Category: Yin Y]] |
| [[Category: Zubcevic, L]] | | [[Category: Zubcevic L]] |
| [[Category: Calcium-permeable ion channel]]
| |
| [[Category: Cold sensor]]
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| [[Category: Ion channel]]
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| [[Category: Menthol sensor]]
| |
| [[Category: Transport protein]]
| |
