6btk: Difference between revisions

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<StructureSection load='6btk' size='340' side='right'caption='[[6btk]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
<StructureSection load='6btk' size='340' side='right'caption='[[6btk]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6btk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BTK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6BTK FirstGlance]. <br>
<table><tr><td colspan='2'>[[6btk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myodes_glareolus Myodes glareolus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BTK FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6axz|6axz]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6btk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6btk OCA], [http://pdbe.org/6btk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6btk RCSB], [http://www.ebi.ac.uk/pdbsum/6btk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6btk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6btk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6btk OCA], [https://pdbe.org/6btk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6btk RCSB], [https://www.ebi.ac.uk/pdbsum/6btk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6btk ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q8VHV5_MYOGA Q8VHV5_MYOGA]
The atomic structure of the infectious, protease-resistant, beta-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the sub-angstrom-resolution structure of a protofibril formed by a wild-type segment from the beta2-alpha2 loop of the bank vole prion protein. The structure of this protofibril reveals a stabilizing network of hydrogen bonds that link polar zippers within a sheet, producing motifs we have named 'polar clasps'.
 
Sub-angstrom cryo-EM structure of a prion protofibril reveals a polar clasp.,Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA Nat Struct Mol Biol. 2018 Jan 15. pii: 10.1038/s41594-017-0018-0. doi:, 10.1038/s41594-017-0018-0. PMID:29335561<ref>PMID:29335561</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6btk" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Prion 3D structures|Prion 3D structures]]
*[[Prion 3D structures|Prion 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Boyer, D R]]
[[Category: Myodes glareolus]]
[[Category: Gallagher-Jones, M]]
[[Category: Boyer DR]]
[[Category: Glynn, C]]
[[Category: Gallagher-Jones M]]
[[Category: Rodriguez, J A]]
[[Category: Glynn C]]
[[Category: Amyloid fibril]]
[[Category: Rodriguez JA]]
[[Category: Polar clasp]]
[[Category: Prion]]
[[Category: Protein fibril]]

Latest revision as of 14:24, 13 March 2024

Segment from bank vole prion protein 168-176 QYNNQNNFV

6btk, resolution 1.10Å

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