6c5r: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
Line 3: Line 3:
<StructureSection load='6c5r' size='340' side='right'caption='[[6c5r]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='6c5r' size='340' side='right'caption='[[6c5r]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c5r]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Metaq Metaq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C5R FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c5r]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Metarhizium_acridum_CQMa_102 Metarhizium acridum CQMa 102]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C5R FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAC_01752 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=655827 METAQ])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.0960832&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c5r OCA], [http://pdbe.org/6c5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c5r RCSB], [http://www.ebi.ac.uk/pdbsum/6c5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c5r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c5r OCA], [https://pdbe.org/6c5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c5r RCSB], [https://www.ebi.ac.uk/pdbsum/6c5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c5r ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/E9DVV4_METAQ E9DVV4_METAQ]
Mitochondrial calcium uptake is critical for regulating ATP production, intracellular calcium signalling, and cell death. This uptake is mediated by a highly selective calcium channel called the mitochondrial calcium uniporter (MCU). Here, we determined the structures of the pore-forming MCU proteins from two fungi by X-ray crystallography and single-particle cryo-electron microscopy. The stoichiometry, overall architecture, and individual subunit structure differed markedly from those described in the recent nuclear magnetic resonance structure of Caenorhabditis elegans MCU. We observed a dimer-of-dimer architecture across species and chemical environments, which was corroborated by biochemical experiments. Structural analyses and functional characterization uncovered the roles of key residues in the pore. These results reveal a new ion channel architecture, provide insights into calcium coordination, selectivity and conduction, and establish a structural framework for understanding the mechanism of mitochondrial calcium uniporter function.


X-ray and cryo-EM structures of the mitochondrial calcium uniporter.,Fan C, Fan M, Orlando BJ, Fastman NM, Zhang J, Xu Y, Chambers MG, Xu X, Perry K, Liao M, Feng L Nature. 2018 Jul 11. pii: 10.1038/s41586-018-0330-9. doi:, 10.1038/s41586-018-0330-9. PMID:29995856<ref>PMID:29995856</ref>
==See Also==
 
*[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6c5r" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Metaq]]
[[Category: Metarhizium acridum CQMa 102]]
[[Category: Fan, C]]
[[Category: Fan C]]
[[Category: Fan, M]]
[[Category: Fan M]]
[[Category: Fastman, N]]
[[Category: Fastman N]]
[[Category: Feng, L]]
[[Category: Feng L]]
[[Category: Zhang, J]]
[[Category: Zhang J]]
[[Category: Cytosolic protein]]

Latest revision as of 14:26, 13 March 2024

Crystal structure of the soluble domain of the mitochondrial calcium uniporter

6c5r, resolution 3.10Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=6c5r&oldid=4090961"