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<SX load='6dwb' size='340' side='right' viewer='molstar' caption='[[6dwb]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<SX load='6dwb' size='340' side='right' viewer='molstar' caption='[[6dwb]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6dwb]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DWB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DWB FirstGlance]. <br>
<table><tr><td colspan='2'>[[6dwb]] is a 30 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DWB FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dwb OCA], [http://pdbe.org/6dwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dwb RCSB], [http://www.ebi.ac.uk/pdbsum/6dwb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dwb ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dwb OCA], [https://pdbe.org/6dwb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dwb RCSB], [https://www.ebi.ac.uk/pdbsum/6dwb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dwb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PRGI_SALTY PRGI_SALTY]] Required for invasion of epithelial cells.  
[https://www.uniprot.org/uniprot/PRGI_SALTY PRGI_SALTY] Required for invasion of epithelial cells.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative bacteria. At the core of the injectisome structure is the needle complex, a continuous channel formed by the highly oligomerized inner and outer membrane hollow rings and a polymerized helical needle filament which spans through and projects into the infected host cell. Here we present the near-atomic resolution structure of a needle complex from the prototypical Salmonella Typhimurium SPI-1 type III secretion system, with local masking protocols allowing for model building and refinement of the major membrane spanning components of the needle complex base in addition to an isolated needle filament. This work provides significant insight into injectisome structure and assembly and importantly captures the molecular basis for substrate induced gating in the giant outer membrane secretin portal family.
 
Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin.,Hu J, Worrall LJ, Hong C, Vuckovic M, Atkinson CE, Caveney N, Yu Z, Strynadka NCJ Nat Commun. 2018 Sep 21;9(1):3840. doi: 10.1038/s41467-018-06298-8. PMID:30242280<ref>PMID:30242280</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6dwb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Hong, C]]
[[Category: Hong C]]
[[Category: Hu, J]]
[[Category: Hu J]]
[[Category: Strynadka, N C.J]]
[[Category: Strynadka NCJ]]
[[Category: Vuckovic, M]]
[[Category: Vuckovic M]]
[[Category: Worrall, L J]]
[[Category: Worrall LJ]]
[[Category: Yu, Z]]
[[Category: Yu Z]]
[[Category: Membrane protein]]
[[Category: Type iii secretion system]]

Latest revision as of 14:37, 13 March 2024

Structure of the Salmonella SPI-1 type III secretion injectisome needle filament

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