6dz7: Difference between revisions

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<SX load='6dz7' size='340' side='right' viewer='molstar' caption='[[6dz7]], [[Resolution|resolution]] 3.89&Aring;' scene=''>
<SX load='6dz7' size='340' side='right' viewer='molstar' caption='[[6dz7]], [[Resolution|resolution]] 3.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6dz7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DZ7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6dz7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus_Af293 Aspergillus fumigatus Af293]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DZ7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AFUA_4G02970 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330879 ASPFU])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.89&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dz7 OCA], [https://pdbe.org/6dz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dz7 RCSB], [https://www.ebi.ac.uk/pdbsum/6dz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dz7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dz7 OCA], [https://pdbe.org/6dz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dz7 RCSB], [https://www.ebi.ac.uk/pdbsum/6dz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dz7 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q4WA18_ASPFU Q4WA18_ASPFU]
The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylserine is exposed to the outer leaflet of membrane, an important step in extracellular signaling networks controlling processes such as apoptosis, blood coagulation, membrane fusion and repair. Several TMEM16 family members have been identified as Ca(2+)-activated scramblases, but the mechanisms underlying their Ca(2+)-dependent gating and their effects on the surrounding lipid bilayer remain poorly understood. Here, we describe three high-resolution cryo-electron microscopy structures of a fungal scramblase from Aspergillus fumigatus, afTMEM16, reconstituted in lipid nanodiscs. These structures reveal that Ca(2+)-dependent activation of the scramblase entails global rearrangement of the transmembrane and cytosolic domains. These structures, together with functional experiments, suggest that activation of the protein thins the membrane near the transport pathway to facilitate rapid transbilayer lipid movement.
 
Structural basis of Ca(2+)-dependent activation and lipid transport by a TMEM16 scramblase.,Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A Elife. 2019 Jan 16;8. pii: 43229. doi: 10.7554/eLife.43229. PMID:30648972<ref>PMID:30648972</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6dz7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Aspfu]]
[[Category: Aspergillus fumigatus Af293]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Accardi, A]]
[[Category: Accardi A]]
[[Category: Falzone, M E]]
[[Category: Falzone ME]]
[[Category: Ca2+-activated]]
[[Category: Lipid transport]]
[[Category: Membrane-reorganization]]
[[Category: Scramblase]]

Latest revision as of 14:37, 13 March 2024

afTMEM16 reconstituted in nanodiscs in the absence of Ca2+

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