6m8h: Difference between revisions

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<StructureSection load='6m8h' size='340' side='right'caption='[[6m8h]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='6m8h' size='340' side='right'caption='[[6m8h]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6m8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M8H FirstGlance]. <br>
<table><tr><td colspan='2'>[[6m8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M8H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gnai1, Gnai-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m8h OCA], [http://pdbe.org/6m8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m8h RCSB], [http://www.ebi.ac.uk/pdbsum/6m8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m8h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m8h OCA], [https://pdbe.org/6m8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m8h RCSB], [https://www.ebi.ac.uk/pdbsum/6m8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m8h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ballicora, M]]
[[Category: Rattus norvegicus]]
[[Category: Goossens, J]]
[[Category: Ballicora M]]
[[Category: Kothawala, S]]
[[Category: Goossens J]]
[[Category: Leverson, B]]
[[Category: Kothawala S]]
[[Category: Liu, D]]
[[Category: Leverson B]]
[[Category: Mascarenhas, R]]
[[Category: Liu D]]
[[Category: Olsen, K]]
[[Category: Mascarenhas R]]
[[Category: Freitas, D de]]
[[Category: Olsen K]]
[[Category: G protein]]
[[Category: De freitas D]]
[[Category: Oncogenic mutation]]
[[Category: Signaling protein]]
[[Category: Switch ii region]]
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