Urokinase

spinqualitylabelsall models Human urokinase light chain fragment (pink) and catalytic domain (yellow) complex with inhibitor and phosphate, 3ig6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Urokinase (UK) or urokinase plasminogen activator or urokinase-type plasminogen activator is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin. UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains. Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage into catalytic domain (residues 179-431) and short chain (residues 156-178). Relevance Increased levels of UK are associated with poor prognosis in patients with breast cancer and thus is used as prognostic markers for the disease. Structural highlights The inhibitor of UK binds in the active site of UK and interacts with the active Ser of the catalytic triad. Water molecules are shown as red spheres. 3D Structures of urokinase Urokinase 3D Structures

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Michal Harel, Alexander Berchansky, Joel L. Sussman