8c3u: Difference between revisions
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==Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist== | |||
<StructureSection load='8c3u' size='340' side='right'caption='[[8c3u]], [[Resolution|resolution]] 1.94Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8c3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C3U FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.945Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T9C:(S)-4-hydroxy-3-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1-biphenyl]-2,4-dicarboxylic+acid'>T9C</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c3u OCA], [https://pdbe.org/8c3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c3u RCSB], [https://www.ebi.ac.uk/pdbsum/8c3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c3u ProSAT]</span></td></tr> | ||
[[Category: Koch | </table> | ||
[[Category: Rondeau | == Function == | ||
[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Koch E]] | |||
[[Category: Lehmann S]] | |||
[[Category: Rondeau J-M]] | |||
Latest revision as of 11:13, 14 March 2024
Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist
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