3r0e: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3r0e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Remusatia_vivipara Remusatia vivipara]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R0E FirstGlance]. <br>
<table><tr><td colspan='2'>[[3r0e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Remusatia_vivipara Remusatia vivipara]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R0E FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kj1|1kj1]], [[1msa|1msa]], [[1dlp|1dlp]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r0e OCA], [https://pdbe.org/3r0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r0e RCSB], [https://www.ebi.ac.uk/pdbsum/3r0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r0e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r0e OCA], [https://pdbe.org/3r0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r0e RCSB], [https://www.ebi.ac.uk/pdbsum/3r0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r0e ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/LEC1_REMVI LEC1_REMVI] Mannose-specific lectin. Shows agglutinating activity towards erythrocytes from rabbit.[UniProtKB:R9RL27]
The crystal structure of a beta-prism II (BP2) fold lectin from Remusatia vivipara, a plant of traditional medicinal value, has been determined at a resolution of 2.4 A. This lectin (RVL) is a dimer with each protomer having two distinct BP2 domains without a linker between them. It belongs to the 'monocot mannose-binding' lectin family, which consists of proteins of high sequence and structural similarity. Though the overall tertiary structure is similar to that of lectins from snowdrop bulbs and garlic, crucial differences in the mannose-binding regions and oligomerization were observed. Unlike most of the other structurally known proteins in this family, only one of the three carbohydrate recognition sites (CRS) per BP2 domain is found to be conserved. RVL does not recognize simple mannose moieties. RVL binds to only N-linked complex glycans like those present on the gp120 envelope-glycoprotein of HIV and mannosylated blood proteins like fetuin, but not to simple mannose moieties. The molecular basis for these features and their possible functional implications to understand the different levels of carbohydrate affinities in this structural family have been investigated through structure analysis, modeling and binding studies. Apart from being the first structure of a lectin to be reported from the Araceae/Arum family, this protein also displays a novel mode of oligomerization among BP2 lectins.
 
Crystal structure of a {beta}-prism II lectin from Remusatia vivipara.,Shetty KN, Bhat GG, Inamdar SR, Swamy BM, Suguna K Glycobiology. 2011 Jul 27. PMID:21788359<ref>PMID:21788359</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3r0e" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Remusatia vivipara]]
[[Category: Remusatia vivipara]]
[[Category: Bhat, G G]]
[[Category: Bhat GG]]
[[Category: Shetty, K N]]
[[Category: Shetty KN]]
[[Category: Suguna, K]]
[[Category: Suguna K]]
[[Category: Swamy, B M]]
[[Category: Swamy BM]]
[[Category: Carbohydrate]]
[[Category: Carbohydrate binding]]
[[Category: Sugar binding protein]]
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