3s3w: Difference between revisions

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<StructureSection load='3s3w' size='340' side='right'caption='[[3s3w]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3s3w' size='340' side='right'caption='[[3s3w]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3s3w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S3W FirstGlance]. <br>
<table><tr><td colspan='2'>[[3s3w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S3W FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACCN2, ASIC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3w OCA], [https://pdbe.org/3s3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s3w RCSB], [https://www.ebi.ac.uk/pdbsum/3s3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3w ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3w OCA], [https://pdbe.org/3s3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s3w RCSB], [https://www.ebi.ac.uk/pdbsum/3s3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK]] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref> 
[https://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref>  
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Venom-derived peptide toxins can modify the gating characteristics of excitatory channels in neurons. How they bind and interfere with the flow of ions without directly blocking the ion permeation pathway remains elusive. Here we report the crystal structure of the trimeric chicken Acid-sensing ion channel 1 in complex with the highly selective gating modifier Psalmotoxin 1 at 3.0 A resolution. The structure reveals the molecular interactions of three toxin molecules binding at the proton-sensitive acidic pockets of Acid-sensing ion channel 1 and electron density consistent with a cation trapped in the central vestibule above the ion pathway. A hydrophobic patch and a basic cluster are the key structural elements of Psalmotoxin 1 binding, locking two separate regulatory regions in their relative, desensitized-like arrangement. Our results provide a general concept for gating modifier toxin binding suggesting that both surface motifs are required to modify the gating characteristics of an ion channel.
 
Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1.,Dawson RJ, Benz J, Stohler P, Tetaz T, Joseph C, Huber S, Schmid G, Hugin D, Pflimlin P, Trube G, Rudolph MG, Hennig M, Ruf A Nat Commun. 2012 Jul 3;3:936. doi: 10.1038/ncomms1917. PMID:22760635<ref>PMID:22760635</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3s3w" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Benz, J]]
[[Category: Benz J]]
[[Category: Dawson, R J.P]]
[[Category: Dawson RJP]]
[[Category: Hennig, M]]
[[Category: Hennig M]]
[[Category: Huber, S]]
[[Category: Huber S]]
[[Category: Huegin, D]]
[[Category: Huegin D]]
[[Category: Joseph, C]]
[[Category: Joseph C]]
[[Category: Pflimlin, P]]
[[Category: Pflimlin P]]
[[Category: Rudolph, M G]]
[[Category: Rudolph MG]]
[[Category: Ruf, A]]
[[Category: Ruf A]]
[[Category: Schmid, G]]
[[Category: Schmid G]]
[[Category: Stohler, P]]
[[Category: Stohler P]]
[[Category: Tetaz, T]]
[[Category: Tetaz T]]
[[Category: Trube, G]]
[[Category: Trube G]]
[[Category: Acid-sensing]]
[[Category: Cell membrane]]
[[Category: Glycoprotein]]
[[Category: Ion channel]]
[[Category: Ion transport]]
[[Category: Membrane]]
[[Category: Membrane glycoprotein]]
[[Category: Membrane protein]]
[[Category: Sodium channel]]
[[Category: Sodium transport]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/3s3w"