3t79: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 3: Line 3:
<StructureSection load='3t79' size='340' side='right'caption='[[3t79]], [[Resolution|resolution]] 3.61&Aring;' scene=''>
<StructureSection load='3t79' size='340' side='right'caption='[[3t79]], [[Resolution|resolution]] 3.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3t79]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T79 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3t79]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T79 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3sqi|3sqi]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6113&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLLA0E03807g ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284590 Candida sphaerica])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t79 OCA], [https://pdbe.org/3t79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t79 RCSB], [https://www.ebi.ac.uk/pdbsum/3t79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t79 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t79 OCA], [https://pdbe.org/3t79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t79 RCSB], [https://www.ebi.ac.uk/pdbsum/3t79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t79 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q6CPM4_KLULA Q6CPM4_KLULA]
Kinetochores link centromeric DNA to spindle microtubules and ensure faithful chromosome segregation during mitosis. In point-centromere yeasts, the CBF3 complex Skp1-Ctf13-(Cep3)(2)-(Ndc10)(2) recognizes a conserved centromeric DNA element through contacts made by Cep3 and Ndc10. We describe here the five-domain organization of Kluyveromyces lactis Ndc10 and the structure at 2.8 A resolution of domains I-II (residues 1-402) bound to DNA. The structure resembles tyrosine DNA recombinases, although it lacks both endonuclease and ligase activities. Structural and biochemical data demonstrate that each subunit of the Ndc10 dimer binds a separate fragment of DNA, suggesting that Ndc10 stabilizes a DNA loop at the centromere. We describe in vitro association experiments showing that specific domains of Ndc10 interact with each of the known inner-kinetochore proteins or protein complexes in budding yeast. We propose that Ndc10 provides a central platform for inner-kinetochore assembly.
 
Ndc10 is a platform for inner kinetochore assembly in budding yeast.,Cho US, Harrison SC Nat Struct Mol Biol. 2011 Dec 4. doi: 10.1038/nsmb.2178. PMID:22139014<ref>PMID:22139014</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3t79" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Candida sphaerica]]
[[Category: Kluyveromyces lactis NRRL Y-1140]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cho, U S]]
[[Category: Cho US]]
[[Category: Harrison, S C]]
[[Category: Harrison SC]]
[[Category: Dna]]
[[Category: Dna binding]]
[[Category: Dna binding protein-dna complex]]
[[Category: Dna recombinase]]

Latest revision as of 13:19, 14 March 2024

Ndc10: a platform for inner kinetochore assembly in budding yeast

3t79, resolution 3.61Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=3t79&oldid=4097934"