3tua: Difference between revisions

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<StructureSection load='3tua' size='340' side='right'caption='[[3tua]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
<StructureSection load='3tua' size='340' side='right'caption='[[3tua]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tua]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TUA FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tua]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TUA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TUA FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tu8|3tu8]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.09&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BPSL1549 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tua OCA], [https://pdbe.org/3tua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tua RCSB], [https://www.ebi.ac.uk/pdbsum/3tua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tua ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tua OCA], [https://pdbe.org/3tua PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tua RCSB], [https://www.ebi.ac.uk/pdbsum/3tua PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tua ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q63UP7_BURPS Q63UP7_BURPS]
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1.
 
A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.,Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW Science. 2011 Nov 11;334(6057):821-4. PMID:22076380<ref>PMID:22076380</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3tua" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus pseudomallei whitmore 1913]]
[[Category: Burkholderia pseudomallei]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Artymiuk, P J]]
[[Category: Artymiuk PJ]]
[[Category: Baker, P J]]
[[Category: Baker PJ]]
[[Category: Chang, C T]]
[[Category: Chang CT]]
[[Category: Cruz, A]]
[[Category: Cruz A]]
[[Category: Hautbergue, G M]]
[[Category: Hautbergue GM]]
[[Category: Mahadi, N M]]
[[Category: Mahadi NM]]
[[Category: Mobbs, G W]]
[[Category: Mobbs GW]]
[[Category: Mohamed, R]]
[[Category: Mohamed R]]
[[Category: Nathan, S]]
[[Category: Nathan S]]
[[Category: Partridge, L J]]
[[Category: Partridge LJ]]
[[Category: Raih, M F]]
[[Category: Raih MF]]
[[Category: Rice, D W]]
[[Category: Rice DW]]
[[Category: Ruzheinikov, S N]]
[[Category: Ruzheinikov SN]]
[[Category: Sedelnikova, S E]]
[[Category: Sedelnikova SE]]
[[Category: Wilson, S A]]
[[Category: Wilson SA]]
[[Category: Toxin]]
[[Category: Unknown function]]
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