3ukb: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ukb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UKB FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ukb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UKB FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=RCE:1-{2,5-ANHYDRO-6-DEOXY-4-[(PHOSPHONOOXY)METHYL]-BETA-D-GULOFURANOSYL}PYRIMIDINE-2,4(1H,3H)-DIONE'>RCE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ukc|3ukc]], [[3uke|3uke]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RCE:1-{2,5-ANHYDRO-6-DEOXY-4-[(PHOSPHONOOXY)METHYL]-BETA-D-GULOFURANOSYL}PYRIMIDINE-2,4(1H,3H)-DIONE'>RCE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ukb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ukb OCA], [https://pdbe.org/3ukb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ukb RCSB], [https://www.ebi.ac.uk/pdbsum/3ukb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ukb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ukb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ukb OCA], [https://pdbe.org/3ukb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ukb RCSB], [https://www.ebi.ac.uk/pdbsum/3ukb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ukb ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications yielded the highly nuclease resistant 2',4'-constrained MOE and ethyl bicyclic nucleic acids (cMOE and cEt BNA, respectively). Crystal structures of DNAs with cMOE or cEt BNA residues reveal their conformational preferences. Comparisons with MOE and LNA structures allow insights into their favourable properties for AON applications.
Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.,Pallan PS, Allerson CR, Berdeja A, Seth PP, Swayze EE, Prakash TP, Egli M Chem Commun (Camb). 2012 May 22. PMID:22614180<ref>PMID:22614180</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ukb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Egli, M]]
[[Category: Egli M]]
[[Category: Pallan, P S]]
[[Category: Pallan PS]]
[[Category: A-form dna]]
[[Category: Antisense oligonucleotide]]
[[Category: Bicyclic nucleic acid]]
[[Category: Bna]]
[[Category: Cet-bna]]
[[Category: Dna]]

Latest revision as of 14:00, 14 March 2024

(R)-cEt-BNA decamer structure

3ukb, resolution 1.42Å

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